MSM (Methylsulfonylmethane) is an organic sulfur compound that supports skin health by promoting collagen production, reducing inflammation, and enhancing antioxidant activity. It is typically used as an oral supplement or topical cream for improving skin elasticity, reducing wrinkles, and treating inflammatory skin conditions.
💡 What You Need to Know Right Away
- MSM at 3g daily for 16 weeks significantly reduced facial wrinkles and skin roughness in human trials[Evidence: B][1]
- Skin hydration improved by 15.2% and elasticity by 22.6% when MSM was combined with hyaluronic acid[Evidence: B][2]
- MSM protects against UV-induced skin damage by preserving collagen and improving elastic fiber integrity[Evidence: C][8]
- MSM has GRAS (Generally Recognized as Safe) status and is well-tolerated at doses up to 4g daily[Evidence: D][4]
If you are researching ways to improve your skin health naturally, you have likely come across MSM. This sulfur-containing compound has gained significant attention in the skincare community for its potential anti-aging and skin-enhancing properties.
It is common to feel overwhelmed when exploring supplement options for skin health. You want something that actually works, backed by real science, not just marketing claims. The good news is that MSM has been studied in multiple clinical trials specifically for skin outcomes.
In this comprehensive guide, you will learn exactly how MSM works for skin, the specific dosages used in research, what results to realistically expect, and important safety considerations. Every claim is supported by peer-reviewed studies so you can make an informed decision.
❓ Quick Answers
What is MSM?
MSM (Methylsulfonylmethane) is an organic sulfur compound naturally found in plants, animals, and humans. Also known as dimethyl sulfone or DMSO2, it provides sulfur that your body uses for building collagen, keratin, and other structural proteins essential for healthy skin.[Evidence: D][4]
How does MSM work for skin?
MSM donates sulfur to support collagen and keratin production while inhibiting inflammatory pathways like NF-κB and NLRP3. It reduces pro-inflammatory cytokines including IL-1β and IL-6, and protects cells through antioxidant activity by enhancing glutathione levels.[Evidence: C][3][7]
What does MSM do for your skin?
Clinical trials show MSM reduces facial wrinkles and skin roughness, improves skin hydration and elasticity, and protects against UV-induced photoaging. One study found 3g daily significantly improved multiple signs of skin aging after 16 weeks.[Evidence: B][1]
How much MSM should I take for skin benefits?
Research shows effective doses range from 1g to 3g daily. Studies specifically examining skin outcomes used 3g daily for optimal results, though 1g daily also demonstrated effectiveness for reducing facial aging signs.[Evidence: B][1]
Is it safe to take MSM every day?
Yes, MSM has GRAS (Generally Recognized as Safe) status from the FDA. Clinical research confirms it is well-tolerated by most individuals at dosages up to 4g daily, with few mild side effects reported in trials lasting up to 16 weeks.[Evidence: D][4]
Does MSM help with wrinkles?
Yes, clinical evidence supports MSM for wrinkle reduction. A human trial demonstrated that 3g MSM daily for 16 weeks significantly reduced facial wrinkles (p < 0.05). Animal studies also show MSM reduces wrinkle scores in UV-exposed skin.[Evidence: B][1][8]
What foods are high in MSM?
MSM occurs naturally in cruciferous vegetables (broccoli, cabbage, Brussels sprouts), alliums (garlic, onions), eggs, and some grains. However, food processing and cooking reduce MSM content significantly. Supplementation provides more consistent and higher doses than dietary sources alone.
MSM Benefits
Methylsulfonylmethane (MSM) is an organic sulfur compound found in nature. Often called the "beauty mineral," it is essential for the production of collagen, keratin, and maintaining healthy, glowing skin.
🔬 How Does MSM Work for Skin?
Think of MSM as a master key that unlocks multiple doors to better skin health. Just as a single key can open several locks in your house, MSM activates several biological pathways simultaneously, each contributing to healthier, younger-looking skin.
Sulfur Donation for Structural Proteins
Your skin relies on sulfur-containing amino acids like cysteine and methionine to build collagen and keratin. MSM serves as a bioavailable sulfur donor, providing the raw material your body needs for protein synthesis. Research shows MSM increases expression of osteogenic markers including osterix, osteopontin, and RUNX2, which play roles in tissue matrix formation.[Evidence: C][10]
Anti-Inflammatory Pathways
Chronic inflammation accelerates skin aging. MSM acts as a selective NLRP3 inflammasome inhibitor, significantly attenuating inflammatory activation in immune cells. It reduces expression of pro-inflammatory cytokines including IL-1α, IL-1β, and IL-6 through mitochondrial ROS reduction.[Evidence: C][3]
MSM also suppresses the NF-κB and ERK/JNK-MAPK signaling pathways, which are central regulators of inflammation. When these pathways are overactivated, they contribute to skin damage and premature aging. By dampening this inflammatory cascade, MSM helps protect skin tissue.[Evidence: C][6][7]
Antioxidant Support
MSM enhances your body's antioxidant defenses. Research in overweight adults showed that 3g MSM daily for 16 weeks resulted in lower C-reactive protein (CRP) levels and improved oxidative status markers.[Evidence: B][12]
Protection Against UV Damage
Imagine your skin cells wearing invisible armor against sun damage. MSM provides this protection by preserving collagen structure and maintaining elastic fiber integrity during UV exposure. In mouse studies, MSM-treated skin showed improved elastic fiber linearity (0.751±0.04 vs 0.551±0.04 in UV-only groups), indicating better preservation of skin structure.[Evidence: C][8]
Melanin Regulation
MSM influences skin pigmentation through the JNK signaling pathway. Research shows MSM treatment resulted in dose-dependent increases in melanin production by elevating MITF and tyrosinase protein expression. This mechanism suggests potential applications for hypopigmentation disorders.[Evidence: C][5]
📊 Dosage and How to Use MSM
Clinical research provides specific guidance on MSM dosing for skin benefits. The table below summarizes the dosages used in peer-reviewed studies.
| Purpose/Condition | Dosage | Duration | Evidence |
|---|---|---|---|
| Facial wrinkles and skin aging (optimal dose) | 3g daily | 16 weeks | [B][1] |
| Facial aging signs (lower effective dose) | 1g daily | 16 weeks | [B][1] |
| Facial skin aesthetics (combined formula) | 400mg daily (with HA + L-carnosine) | 60 days | [B][2] |
| Anti-inflammatory effects | 2g daily | 12 weeks | [B][11] |
| Antioxidant and CRP reduction | 3g daily | 16 weeks | [B][12] |
| General supplementation (safety ceiling) | Up to 4g daily | Variable | [D][4] |
Best Time to Take MSM
MSM can be taken with or without food. Some people prefer taking it with meals to minimize any potential digestive discomfort. Clinical trials did not specify required timing with food, so personal preference applies.
Can You Combine MSM with Other Supplements?
Yes, MSM shows synergistic effects with other skin-supporting nutrients. One RCT combined 400mg MSM with 200mg hyaluronic acid and 500mg L-carnosine, demonstrating significant improvements in skin hydration and elasticity.[Evidence: B][2] Another study combined MSM with hydrolyzed collagen, glucosamine, and chondroitin for joint and connective tissue support.[Evidence: B][9]
⚠️ Risks, Side Effects, and Warnings
Side Effects
Clinical research reports few mild side effects with MSM supplementation. The comprehensive safety review notes that adverse events are generally mild and infrequent at recommended doses.[Evidence: D][4] Specific frequency data from skin-focused studies was not quantified, but no serious adverse events were reported in trials lasting up to 16 weeks.
Potential mild side effects based on general supplement literature include digestive discomfort, headache, and fatigue. These typically resolve with continued use or dose adjustment.
Drug Interactions
Specific drug interaction studies for MSM have not been published. Given MSM's anti-inflammatory properties affecting pathways like NF-κB and inflammatory cytokines[3][7], theoretical interactions with anti-inflammatory medications, blood thinners, or immunomodulatory drugs may exist. Inform your healthcare provider of all medications before starting MSM.
Contraindications
No absolute contraindications are established in clinical literature for MSM. However, exercise caution in the following situations:
- Pregnancy and breastfeeding: Human safety data not established. Consult healthcare provider.
- Sulfur sensitivity or allergy: Avoid if you have known reactions to sulfur compounds.
- Scheduled surgery: Discontinue use 2 weeks before surgery as a precaution given potential anti-inflammatory effects.
Monitoring Recommendations
No specific biomarker monitoring protocols are established for MSM supplementation. General recommendations include monitoring for adverse reactions and consulting your healthcare provider regularly when using supplements.
🥗 Practical Ways to Use MSM for Skin
How to Use This in Your Daily Life
Scenario 1: General Skin Anti-Aging
- Dose: 3g daily[1]
- Duration: 16 weeks minimum[1]
- Population: Healthy adults concerned with skin aging
- Timing: With meals
- What to track: Wrinkle appearance, skin texture, hydration
- Expected results: Significant reduction in facial wrinkles and skin roughness (p < 0.05); improved firmness, elasticity, and hydration[1]
Scenario 2: Enhanced Skin Hydration (Combination Approach)
- Dose: 400mg MSM + 200mg Hyaluronic Acid + 500mg L-carnosine[2]
- Duration: 60 days[2]
- Population: Adults with facial skin photoaging
- What to track: Skin hydration, elasticity measurements
- Expected results: Hydration +15.2%, elasticity +22.6%, sebum production -24.2%[2]
Practical Integration
Take MSM with breakfast or lunch. Powder form can be mixed into water, juice, or smoothies. Capsules should be taken with a full glass of water. Store in a cool, dry place away from direct sunlight.
Common Mistakes to Avoid
- Expecting overnight results: Studies showing benefits used MSM for 8-16 weeks[1][2]. Skin cell turnover takes time.
- Inconsistent dosing: Clinical trials used daily dosing[1]. Sporadic use may not achieve documented benefits.
- Using too low a dose: While 1g showed some effect, 3g daily demonstrated superior outcomes for skin aging[1].
- Not combining strategically: MSM works synergistically with hyaluronic acid and L-carnosine[2].
Topical vs Oral MSM
Most clinical research focuses on oral MSM supplementation. While topical MSM creams exist commercially, quantified bioavailability data for topical application was not found in the reviewed studies. Oral supplementation has the strongest evidence base for skin benefits.
⚖️ MSM vs Other Skin Supplements
How does MSM compare to other popular skin health supplements? This comparison helps you understand where MSM fits in your skincare strategy.
| Feature | MSM | Collagen | Hyaluronic Acid |
|---|---|---|---|
| Primary Mechanism | Sulfur donation, anti-inflammatory, antioxidant | Provides collagen peptides directly | Hydration and moisture retention |
| Main Skin Benefits | Wrinkle reduction, elasticity, UV protection | Skin elasticity, wrinkle reduction | Hydration, plumpness |
| Typical Daily Dose | 1-3g | 2.5-10g | 120-240mg |
| Time to Results | 8-16 weeks | 8-12 weeks | 4-8 weeks |
| Can Combine? | Yes, synergistic with HA and collagen | Yes, works well with MSM | Yes, enhances MSM effects |
| Best For | Anti-aging, inflammation, UV damage | Structural skin support | Dry, dehydrated skin |
Synergy Between MSM and Collagen
MSM and collagen work through complementary mechanisms. MSM provides sulfur for your body's own collagen synthesis while reducing inflammation that degrades existing collagen. Collagen supplements provide pre-formed peptides. A study combining MSM with hydrolyzed collagen demonstrated 96.77% patient compliance and significant improvements in connective tissue health (p<0.001).[Evidence: B][9]
For comprehensive skin support, consider combining MSM with both collagen and hyaluronic acid. Research demonstrates this multi-ingredient approach yields improvements in hydration, elasticity, and wrinkle reduction simultaneously.[2]
What The Evidence Shows (And Doesn't Show)
What Research Suggests
- Oral MSM at 3g daily for 16 weeks significantly reduces facial wrinkles and skin roughness (p < 0.05) based on human clinical trials (n=83 total across pilot and dose-response phases)[1]
- MSM combined with hyaluronic acid improves skin hydration by 15.2% and elasticity by 22.6% after 60 days (RCT, n=60)[2]
- MSM inhibits NLRP3 inflammasome activation and reduces pro-inflammatory cytokines IL-1α, IL-1β, and IL-6 via mitochondrial ROS reduction (in vitro studies)[3]
- MSM protects against UV-induced skin damage, reducing wrinkle scores and preserving elastic fiber integrity in animal models[8]
- MSM at 3g daily reduces C-reactive protein (CRP) levels, indicating systemic anti-inflammatory effects (RCT, n=22)[12]
What's NOT Yet Proven
- No systematic review or meta-analysis on MSM specifically for skin outcomes exists. Evidence relies on individual RCTs and mechanistic studies.
- Optimal dosage not definitively established. Studies used doses ranging from 1g to 3g with varying results. Dose-response relationship needs further clarification.
- Long-term safety beyond 16 weeks not documented in skin-specific human trials.
- Topical MSM bioavailability and efficacy not quantified in peer-reviewed research.
- Specific effects on acne, rosacea, and other inflammatory skin conditions not directly studied in clinical trials.
- Effects in children, pregnant women, and elderly populations not examined in skin-focused research.
Where Caution Is Needed
- Most skin evidence comes from 2 primary human trials.[1][2] Replication in larger, independent studies is needed.
- One combination study used MSM with other active ingredients (HA, L-carnosine)[2], making it difficult to isolate MSM's specific contribution.
- Pregnancy and lactation safety data comes from animal studies only. Human safety not established.
- Drug interaction potential with anti-inflammatory medications, blood thinners, or immunomodulatory drugs is theoretically possible given MSM's mechanisms.[3][7]
- Quality varies between commercial MSM products. Look for OptiMSM or similar purity-verified sources.
Should YOU Try This?
Best suited for: Adults concerned with skin aging (wrinkles, elasticity loss, roughness), individuals seeking natural anti-inflammatory support for skin health, and those interested in UV protection supplementation.
Not recommended for: Pregnant or breastfeeding women without physician approval, individuals with sulfur allergies, those scheduled for surgery within 2 weeks, and anyone taking medications without consulting their healthcare provider first.
Realistic timeline: Based on clinical evidence, expect 8-16 weeks of consistent daily use before visible improvements in wrinkles and skin texture.[1][2]
When to consult a professional: Before starting if you take any medications, have underlying health conditions, are pregnant or breastfeeding, or if you experience any adverse reactions after beginning supplementation.
Frequently Asked Questions
How long does it take for MSM to work for skin?
Based on clinical research, expect initial subtle improvements in skin texture around 4-8 weeks, with more visible results for wrinkles and elasticity at 8-16 weeks. The primary skin aging study used 16 weeks of supplementation at 3g daily to demonstrate significant reductions in wrinkles and roughness. A study combining MSM with hyaluronic acid showed measurable improvements at 60 days. Individual response varies based on baseline skin condition, age, and adherence to dosing.
Does MSM tighten skin?
MSM supports skin firmness and elasticity rather than providing immediate tightening. Clinical evidence shows MSM supplementation improves skin elasticity by supporting collagen structure and reducing inflammatory damage. One study found elasticity improvements of 15.9-22.6% in different facial areas after 60 days when MSM was combined with hyaluronic acid. Animal research demonstrates MSM preserves elastic fiber integrity during UV exposure. These improvements translate to firmer-feeling skin over time.
Can MSM cause skin problems?
Clinical trials have not reported MSM causing skin problems. In fact, MSM demonstrates anti-inflammatory properties that may benefit inflammatory skin conditions. The compound reduces pro-inflammatory cytokines like IL-1β and IL-6 and suppresses NF-κB activation, pathways involved in skin inflammation. However, individuals with sulfur sensitivity should exercise caution. If you experience any skin reactions after starting MSM, discontinue use and consult a healthcare provider.
Is MSM better than collagen for skin?
MSM and collagen work through different mechanisms, so neither is universally 'better.' MSM provides sulfur for your body to make its own collagen while reducing inflammation and oxidative damage. Collagen supplements provide pre-formed peptides for direct use. Research shows combining them may be optimal. A study using MSM with hydrolyzed collagen demonstrated significant improvements with 96.77% compliance. Consider using both for comprehensive skin support.
Can you apply MSM directly to skin?
While topical MSM products exist commercially, the strongest clinical evidence for skin benefits comes from oral supplementation. The studies demonstrating wrinkle reduction and elasticity improvements used oral MSM at 1-3g daily. Quantified bioavailability data for topical MSM penetration was not found in the reviewed clinical literature. If using topical MSM, consider it supplementary to oral intake rather than a replacement.
Does MSM help with acne scars?
Direct clinical evidence for MSM treating acne scars specifically was not found in the reviewed studies. However, MSM's mechanisms suggest potential benefit: it supports collagen production for skin repair, reduces inflammation that can worsen scarring, and improves overall skin texture and elasticity. These effects may indirectly support scar healing, but specific efficacy for acne scars requires dedicated research.
Does MSM increase collagen production?
Yes, MSM supports collagen synthesis through sulfur donation. Sulfur is essential for the amino acids cysteine and methionine used in collagen formation. Research shows MSM increases expression of tissue matrix proteins and enhances protein cross-linking through the transglutaminase-2 (TG2) mechanism. MSM also protects existing collagen from UV-induced damage, preserving collagen structure during photoaging. This dual action of supporting new collagen and protecting existing collagen explains its anti-aging effects.
Can MSM cause skin breakouts?
Clinical research has not documented MSM causing breakouts or acne. Some anecdotal reports mention initial skin 'purging,' but this is not validated in peer-reviewed literature. In fact, MSM may benefit acne-prone skin through its anti-inflammatory properties, reducing pro-inflammatory cytokines IL-1β and IL-6 that contribute to acne inflammation. If you experience breakouts after starting MSM, consider other factors like product quality or concurrent dietary changes. Consult a dermatologist if concerns persist.
Our Accuracy Commitment and Editorial Principles
At Biochron, we take health information seriously. Every claim in this article is supported by peer-reviewed scientific evidence from reputable sources published in 2015 or later. We use a rigorous evidence-grading system to help you understand the strength of research behind each statement:
- [Evidence: A] = Systematic review or meta-analysis (strongest evidence)
- [Evidence: B] = Randomized controlled trial (RCT)
- [Evidence: C] = Cohort or case-control study
- [Evidence: D] = Expert opinion or clinical guideline
Our editorial team follows strict guidelines: we never exaggerate health claims, we clearly distinguish between correlation and causation, we update content regularly as new research emerges, and we transparently note when evidence is limited or conflicting. For our complete editorial standards, visit our Editorial Principles page.
This article is for informational purposes only and does not constitute medical advice. Always consult qualified healthcare professionals before making changes to your health regimen, especially if you have medical conditions or take medications.
References
- 1 . Beauty from within: Oral administration of a sulfur-containing supplement methylsulfonylmethane improves signs of skin ageing, International Journal of Vitamin and Nutrition Research, 2022, PubMed [Evidence: B]
- 2 . Randomized, Placebo-controlled Study of a Nutraceutical Based on Hyaluronic Acid, L-carnosine, and Methylsulfonylmethane in Facial Skin Aesthetics and Well-being, Journal of Clinical and Aesthetic Dermatology, 2019, PubMed [Evidence: B]
- 3 . Methylsulfonylmethane inhibits NLRP3 inflammasome activation, Cytokine, 2015, PubMed [Evidence: C]
- 4 . Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement, Nutrients, 2017, PubMed [Evidence: D]
- 5 . Methylsulfonylmethane promotes melanogenesis via activation of JNK in Mel-Ab cells, International Journal of Cosmetic Science, 2024, PubMed [Evidence: C]
- 6 . Methylsulfonylmethane ameliorates inflammation via NF-κB and ERK/JNK-MAPK signaling pathway, Poultry Science, 2022, PubMed [Evidence: C]
- 7 . Methylsulfonylmethane decreases inflammatory response to tumor necrosis factor-α in cardiac cells, American Journal of Cardiovascular Diseases, 2018, PubMed [Evidence: C]
- 8 . Effects of Methylsulfonylmethane on UVB-induced Skin Damage: An Experimental Study in a Mouse Model, In Vivo, 2022, PubMed [Evidence: C]
- 9 . The effect of combined hydrolyzed type 2 collagen, methylsulfonylmethane, glucosamine sulfate and chondroitin sulfate supplementation on knee osteoarthritis symptoms, Turkish Journal of Physical Medicine and Rehabilitation, 2024, PubMed [Evidence: B]
- 10 . Methylsulfonylmethane increases osteogenesis and regulates the mineralization of the matrix by transglutaminase 2 in SHED cells, PLoS One, 2019, PubMed [Evidence: C]
- 11 . Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial, Nutrients, 2023, PubMed [Evidence: B]
- 12 . The Effect of Daily Methylsulfonylmethane (MSM) Consumption on High-Density Lipoprotein Cholesterol in Healthy Overweight and Obese Adults: A Randomized Controlled Trial, Nutrients, 2021, PubMed [Evidence: B]
Medical Disclaimer
This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers are advised to consult their doctors or qualified health professionals regarding specific health questions and before making any changes to their health routine, including starting new supplements.
Neither Biochron nor the author takes responsibility for possible health consequences of any person reading or following the information in this educational content. All readers, especially those taking prescription medications, should consult their physicians before beginning any nutrition, supplement, or lifestyle program.
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