Functional Wellness

Spore-Based Probiotics (SBOs): Survivability, SIBO & Gut Health

Spore-Based Probiotics (SBOs): Survivability, SIBO & Gut Health

💡 What You Need to Know Right Away

Spore-based probiotics are supplements that contain spore-forming Bacillus bacteria, which survive stomach acid and support gut health by boosting beneficial bacteria, reducing inflammation, and strengthening the gut lining.

Also known as: Bacillus spore probiotics, spore-forming probiotics, soil-based probiotics, SBOs

  • Research shows spore-based probiotics helped reduce diarrhea duration and hospital stays in children with stomach infections[Evidence: A][1]
  • Studies suggest high-dose spore-based probiotics helped speed recovery by about 3 days and reduced antibiotic use by 25% in children with ongoing diarrhea[Evidence: B][3]
  • Research shows spore-based probiotics helped prevent diarrhea in people taking antibiotics and can be taken at the same time as antibiotics[Evidence: A][6]
  • Studies suggest spore-based probiotics (B. coagulans and B. subtilis) have been tested and found safe, with no harmful genes detected[Evidence: B][4]

If you have been exploring ways to support your gut health, you have probably heard about spore-based probiotics. These unique supplements work differently from the yogurt-based probiotics you may already know. They form protective shells that help them survive the harsh journey through your stomach acid.

It is common to feel uncertain about trying a new type of probiotic, especially with unfamiliar bacteria strains. Many people worry about side effects or whether these supplements actually work. The good news is that recent research provides clear guidance on both safety and effectiveness.

In this guide, you will learn how spore-based probiotics work, what the research shows about their benefits, proper dosage, potential side effects, and who should avoid them. We will help you make an informed decision about whether spore-based probiotics are right for you.

❓ Quick Answers

What are spore-based probiotics?

Spore-based probiotics are supplements containing Bacillus bacteria that form protective shells called endospores. These shells allow the bacteria to survive stomach acid and reach your intestines intact. Common strains include Bacillus subtilis, Bacillus coagulans, and Bacillus clausii. Unlike regular probiotics that may die in stomach acid, spore probiotics are shelf-stable and do not require refrigeration.

How do spore probiotics work?

Spore probiotics work through a unique survival mechanism. They enter your digestive system in a dormant spore form, protected by a tough outer shell. Once they reach your intestines, they "wake up" and become active bacteria. Studies suggest they then produce beneficial compounds and help support healthy gut bacteria balance[Evidence: B][2].

What is the difference between spore probiotics and regular probiotics?

Spore probiotics form protective shells that survive stomach acid, while regular probiotics (like Lactobacillus) are more vulnerable to acidic conditions. Spore probiotics are shelf-stable and do not need refrigeration. Regular probiotics often require cold storage. Spore probiotics work by reconditioning your existing gut bacteria rather than trying to colonize permanently[Evidence: D][5].

Do spore probiotics need to be refrigerated?

No, spore-based probiotics are shelf-stable and do not need refrigeration. The protective spore shell keeps the bacteria dormant and viable at room temperature. This is a major advantage over traditional probiotics that often require cold storage. Store them in a cool, dry place away from direct sunlight for up to 2 years.

How long does it take for spore probiotics to work?

Side effects like temporary bloating or gas typically resolve within 2-3 days. Initial benefits may appear within 2 weeks of consistent use. Full microbiome reconditioning typically takes 2-3 months. Studies in children with diarrhea showed benefits appearing within 5 days[Evidence: B][3].

Are spore-based probiotics safe?

Studies suggest spore-based probiotics are generally safe for most people. Multiple genomic safety assessments have confirmed the absence of harmful toxin genes and problematic antibiotic resistance[Evidence: B][4]. Studies suggest B. subtilis strains showed no adverse effects on liver, kidney, or heart function in humans[Evidence: C][10].

How much spore probiotic should I take?

Start with a low dose (half capsule or 1 capsule every other day) during the first week to minimize adjustment symptoms. Gradually increase to 1-2 capsules daily by week 3. Take with food for best results. Specific dosing varies by product and condition. Studies in children used formulations around 2×10⁹ CFU per dose[Evidence: A][1].

Science Series

The Spore Advantage

Unlike traditional probiotics, spore-based strains (Bacillus) are equipped with a natural armor. Discover how this biological mechanism revolutionizes gut restoration, immunity, and overall well-being.

🔬 How Do Spore Probiotics Work?

Spore-based probiotics have a unique survival strategy that sets them apart from regular probiotics. Think of spore-forming bacteria like seeds that can survive harsh winters. Just as seeds have a tough outer coating that protects them until conditions are right for growth, Bacillus bacteria form protective shells called endospores that shield them from stomach acid, heat, and other challenges.

The Spore Formation and Germination Process

When you swallow a spore-based probiotic capsule, the bacteria are in a dormant "sleeping" state inside their protective shells. These spores travel safely through your acidic stomach, which would destroy most regular probiotics. Once they reach your small intestine, the spores sense the more favorable environment. Like a sensor detecting the right conditions, they "wake up" and transform into active bacteria. This process is called germination.

Microbiome Reconditioning

Unlike regular probiotics that try to permanently colonize your gut, spore probiotics work by reconditioning your existing gut environment. Studies suggest a five-strain spore-based probiotic formula may help support healthy gut bacteria balance and digestive metabolism[Evidence: B][2]. Rather than replacing your native bacteria, they help create conditions where beneficial bacteria can thrive.

Short-Chain Fatty Acid Production

Once active, Bacillus strains produce beneficial compounds including short-chain fatty acids (SCFAs) like butyrate, acetate, and propionate. These compounds nourish the cells lining your intestines and help maintain gut barrier integrity. Early research suggests spore-based probiotics may help support the gut's protective barrier, provide antimicrobial benefits, and support immune function[Evidence: D][5].

Antimicrobial Compounds

Bacillus bacteria also produce natural antimicrobial compounds. Early research suggests spore-based probiotics produce natural compounds like surfactin, fengycin, iturin A, and bacteriocins that may help fight harmful bacteria[Evidence: D][8]. This antimicrobial activity may help maintain a healthy balance between good and bad bacteria in your gut.

🧪 What to Expect: The Real User Experience

Sensory Profile

Most spore-based probiotics come in capsule form, so you will not taste or smell the probiotic itself. The capsules are typically standard supplement size, similar to fish oil capsules. Some products offer powder form with a fine, dry texture similar to cornstarch, though this is less common.

Common User Experiences

About 40% of users report temporary die-off symptoms during the first 2-3 days. Many people describe these as "detox-like" symptoms: gas, bloating, mild abdominal cramping, or loose stools. It is common to feel uncomfortable during this adjustment period. These experiences are normal and typically resolve quickly. About 30% of users report needing 1-2 weeks to fully acclimate before feeling comfortable with the full dosage.

Practical Usage Tips

  • Take with food: Taking spore probiotics 15-20 minutes after eating helps spore germination. Carbohydrates and amino acids trigger activation.
  • Start low and slow: Begin with half a capsule or 1 capsule every other day to minimize die-off symptoms.
  • Titration protocol: Week 1: 1/2-1 capsule every other day. Week 2: 1 capsule daily. Week 3+: 2 capsules daily.
  • Stay hydrated: Increase water intake during the first week to support the adjustment process.
  • Reduce dose if needed: If side effects persist beyond 3 days, drop back to a lower dose and increase more gradually.
  • Storage: Keep in a cool, dry place. No refrigeration needed. Shelf-stable up to 2 years.

Form Preferences

About 95% of users prefer capsules for convenience, no taste, and precise dosing. The powder form is preferred by a small minority who have difficulty swallowing pills or want to mix into food or smoothies. However, powder has a chalky texture and may activate prematurely if mixed with acidic liquids.

📊 Dosage and How to Use

Dosing spore-based probiotics correctly helps maximize benefits while minimizing temporary side effects. Clinical studies have used varying dosages depending on the specific strain and condition being addressed.

Purpose/Condition Dosage Duration Evidence
Acute gastroenteritis (children) 2×10⁹ CFU per dose As directed [A][1]
Irritable bowel syndrome (adults) Per product label (B. coagulans single-strain) As per protocol [B][9]
Functional bloating/gas (adults) Per product label (B. subtilis) As per trial protocol [B][12]
General gut support (titration) Week 1: 1/2-1 capsule EOD
Week 2: 1 capsule daily
Week 3+: 2 capsules daily
Ongoing Clinical practice

Best Time to Take Spore Probiotics

Take spore-based probiotics with food, ideally 15-20 minutes after eating. Food provides the nutrients (carbohydrates and amino acids) that help trigger spore germination. Taking them on an empty stomach may increase gas and bloating. Morning or evening timing is based on personal preference, as there is no significant difference in effectiveness.

Important Dosage Considerations

Studies in children with persistent diarrhea used high-dose multi-strain formulations that enhanced treatment efficacy by about 60% compared to standard care[Evidence: B][3]. However, specific CFU counts vary by product. Always follow the dosing instructions on your specific product label or consult your healthcare provider for personalized guidance.

⚠️ Risks, Side Effects, and Warnings

Spore-based probiotics may interact with immunosuppressant medications and should be used with caution in people with compromised immune systems. It is common to worry about starting a new supplement. Here is what you need to know about safety.

Side Effects by Frequency

Reported side effects from clinical trials and user experiences include:

  • Common (first 2-3 days): Gas, bloating, mild abdominal cramping, loose stools (die-off reaction)
  • Uncommon: Prolonged digestive adjustment (1-2 weeks in some users)
  • Rare: Serious adverse events were not commonly reported in clinical trials

Safety Profile by Strain

Studies suggest one strain of spore-based probiotic (B. coagulans JBI-YZ6.3) has been tested and found safe for use, with no harmful genes detected[Evidence: B][4]. Studies suggest B. subtilis CU1 has been tested in humans and found safe, with no negative effects on liver, kidney, or heart function[Evidence: C][10]. Studies suggest B. subtilis MB40 has been tested and found safe for use in foods and supplements, with no harmful genes detected[Evidence: C][11].

Antibiotic Co-Administration

Research shows spore-based probiotics can be taken at the same time as antibiotics because B. clausii strains resist being killed by many common antibiotics[Evidence: A][6]. This polyantbiotic resistance is a benefit, allowing the probiotic to survive and work while you take prescribed antibiotics.

Contraindications

  • Severe immunocompromise: Caution advised per FDA guidance. Risk of bacteremia in premature infants and severely immunodeficient patients.
  • Pregnancy and lactation: No human safety data found in recent literature (post-2015). Consult your healthcare provider.
  • Central venous catheters: Caution advised per FDA guidance.

When to Seek Medical Attention

  • Symptoms persist beyond 1 week despite dose reduction
  • Signs of infection (fever, severe abdominal pain)
  • Blood in stool
  • Severe allergic reaction

🥗 Practical Ways to Use Spore Probiotics

How to Use This in Your Daily Life

For Digestive Support (General Wellness)

  • Dose: 1-2 capsules daily after titration period
  • Duration: Ongoing (consistent daily use)
  • Population: Adults seeking digestive support
  • Timing: With breakfast or dinner
  • What to track: Bloating, gas, bowel regularity, energy levels
  • Expected results: Improvements in gas and bloating symptoms over 2-8 weeks[Evidence: B][12]

For Irritable Bowel Syndrome Support

  • Dose: Per product label (B. coagulans single-strain formulations studied)
  • Duration: As per protocol (studies varied)
  • Population: Adults with IBS
  • Timing: With meals
  • What to track: Bowel satisfaction, symptom severity, stool consistency
  • Expected results: Improvements in bowel satisfaction and symptom relief compared to placebo[Evidence: B][9]

During Antibiotic Treatment

  • Dose: Per product label (B. clausii strains studied)
  • Duration: During antibiotic course and 1-2 weeks after
  • Population: Children and adults taking antibiotics
  • Timing: With meals (can be taken same day as antibiotics)
  • What to track: Stool frequency, consistency, abdominal discomfort
  • Expected results: Reduced diarrheal frequency and duration[Evidence: B][13]

Common Mistakes to Avoid

  • Starting at full dose: This increases die-off symptoms. Always titrate slowly.
  • Taking on empty stomach: Food helps spore activation. Take with meals.
  • Inconsistent use: Studies used daily dosing. Sporadic use may not achieve benefits.
  • Expecting immediate results: Full microbiome reconditioning takes 2-3 months.
  • Breaking capsules: Keep capsules intact to protect spores until they reach intestines (unless mixing powder form is intended).

What to Look for When Choosing Spore Probiotics

Not all spore-based probiotic supplements are created equal. Here is what matters when selecting a quality product:

Quality Markers

  • Third-party testing: Look for USP, NSF, or ConsumerLab certification Why it matters: Verifies ingredient accuracy, purity, and potency since supplements are not FDA-regulated
  • Strain identification: Labels should specify strains (e.g., Bacillus subtilis, Bacillus coagulans, Bacillus clausii) Why it matters: Different strains have different research profiles. Clinical studies used specific identified strains[1][9]
  • CFU count: Look for products with labeled CFU (colony-forming units) counts Why it matters: Studies used formulations around 2×10⁹ CFU per dose[1]
  • Minimal additives: Avoid unnecessary fillers, artificial colors, or allergens Why it matters: Reduces risk of adverse reactions and ensures you are getting what you pay for
  • Shelf stability claims: Should not require refrigeration Why it matters: True spore-based probiotics are naturally shelf-stable. Refrigeration requirements may indicate non-spore formulations

Red Flags to Avoid

  • Proprietary blends: Cannot verify individual strain amounts
  • Unrealistic claims: "Cure," "miracle," or "guaranteed results" language
  • No strain identification: Just says "probiotic blend" without specifying Bacillus strains
  • Suspiciously cheap: Quality spore-based probiotics require specialized manufacturing
  • No batch testing: Quality varies without independent verification

Where to Buy

  • Best: Pharmacies with licensed pharmacists, reputable health stores, healthcare practitioner channels
  • Caution: Online marketplaces (Amazon, eBay). Verify seller authenticity, check for tamper seals, review customer feedback
  • Avoid: Unregulated websites, pop-up ads, multi-level marketing schemes with unverified claims

How Spore Probiotics Compare to Regular Probiotics: What to Know

Spore-based probiotics and regular probiotics work through different mechanisms to support gut health. They are not direct substitutes for each other, but rather offer different advantages depending on your needs.

Feature Spore-Based Probiotics Regular Probiotics (Lactobacillus, Bifidobacterium)
Stomach Acid Survival High. Protective spore shell survives acidic conditions[Evidence: D][5] Variable. Many strains are vulnerable to stomach acid
Storage Requirements Shelf-stable. No refrigeration needed Often require refrigeration to maintain viability
Mechanism of Action Reconditioning. Supports existing gut bacteria[Evidence: B][2] Colonization. Attempts to establish presence in gut
Antibiotic Co-Administration Can be taken with antibiotics (polyantbiotic-resistant strains)[Evidence: A][6] Varies. Some strains killed by antibiotics
Research Base Growing. Recent clinical trials show promise[Evidence: B][3] Extensive. Decades of clinical research
Common Strains Bacillus subtilis, B. coagulans, B. clausii Lactobacillus acidophilus, Bifidobacterium longum

What The Evidence Shows (And Doesn't Show)

What Research Suggests

The evidence base for spore-based probiotics is growing, with moderate-strength evidence from recent clinical trials:

  • Research shows spore-based probiotics helped reduce diarrhea duration, stool frequency, and hospital stays in children with acute gastroenteritis (meta-analysis of 11 RCTs)[Evidence: A][1]
  • Studies suggest high-dose multi-strain formulations helped speed recovery by about 3 days and reduced antibiotic use by 25% in children with persistent diarrhea[Evidence: B][3]
  • Research shows B. clausii strains are effective for preventing antibiotic-associated diarrhea (systematic review)[Evidence: A][6]
  • Studies suggest B. coagulans helps improve bowel satisfaction and symptoms in adults with IBS[Evidence: B][9]
  • Studies suggest B. subtilis helps reduce intestinal gas symptoms and improves quality of life in adults with functional bloating[Evidence: B][12]

What's NOT Yet Proven

  • Optimal dosage not established: Studies used varying CFU counts from 10⁷ to 10⁹. No standardized therapeutic dose exists.
  • Long-term effects beyond study durations: Most trials lasted weeks to months. Long-term effects over years are not well studied.
  • Pregnancy and lactation safety: No 2015+ studies found specifically assessing safety in pregnant or breastfeeding women.
  • Superiority over regular probiotics: Head-to-head comparisons are limited. Both types may have different roles.
  • Specific benefits for SIBO: Theoretical benefits exist, but direct clinical trials for SIBO are lacking.

Where Caution Is Needed

  • Immunocompromised individuals should consult healthcare providers before use. FDA guidance notes potential risks.
  • Quality varies by product. Third-party testing is essential since supplements are not FDA-regulated for efficacy.
  • Die-off reactions are common (40% of users) and may be uncomfortable during initial days[Evidence: D][5]
  • Taxonomic names are evolving (B. clausii now classified as Shouchella clausii, B. coagulans as Heyndrickxia coagulans in some databases)

Should YOU Try This?

Best suited for: Adults and children seeking digestive support, people taking antibiotics, adults with IBS or functional bloating, those who prefer shelf-stable supplements

Not recommended for: Severely immunocompromised individuals, premature infants, those with central venous catheters, pregnant/breastfeeding women without medical supervision

Realistic timeline: Side effects resolve in 2-3 days. Initial benefits within 2 weeks. Full microbiome reconditioning in 2-3 months.

When to consult a professional: Before starting if you have serious health conditions, take prescription medications, are immunocompromised, or are pregnant/breastfeeding.

Frequently Asked Questions

Can I take spore probiotics every day?

Yes, spore-based probiotics are designed for daily use. Clinical studies typically used daily dosing protocols to achieve benefits. Consistent daily use appears to be more effective than sporadic supplementation. After completing the initial titration period (starting low and gradually increasing over 2-3 weeks), most people take 1-2 capsules daily with food. There is no evidence suggesting a need for 'breaks' from supplementation.

What are the side effects of spore probiotics?

The most common side effects are temporary digestive symptoms during the first 2-3 days, often called a 'die-off' or Herxheimer reaction. These include gas, bloating, mild abdominal cramping, and loose stools. About 40% of users report some adjustment symptoms. These typically resolve within 2-3 days and can be minimized by starting with a low dose and increasing gradually. Serious side effects are rare in healthy individuals.

Who should not take spore probiotics?

People who are severely immunocompromised, premature infants, or those with central venous catheters should use caution and consult their healthcare provider before taking spore-based probiotics. FDA guidance suggests potential risks in these populations. Pregnant and breastfeeding women should consult their healthcare provider as there is limited safety data specifically for pregnancy. If you have a serious health condition, always discuss with your doctor first.

Are spore probiotics good for SIBO?

Some healthcare practitioners recommend spore-based probiotics for people with SIBO (small intestinal bacterial overgrowth) because they are less likely to worsen symptoms compared to traditional probiotics. The theory is that spore probiotics work by reconditioning rather than adding more bacteria to an already overpopulated small intestine. However, specific clinical trials on spore probiotics for SIBO are limited. Consult a healthcare provider experienced with SIBO for personalized guidance.

What strains are in spore probiotics?

The most common strains in spore-based probiotic supplements include Bacillus subtilis, Bacillus coagulans, and Bacillus clausii. Some multi-strain formulations also include Bacillus indicus and Bacillus licheniformis. Each strain has slightly different benefits. B. coagulans has been studied for IBS. B. clausii has been studied for antibiotic-associated diarrhea.

Do spore probiotics survive stomach acid?

Yes, surviving stomach acid is one of the main advantages of spore-based probiotics. The bacteria form a protective outer shell called an endospore that shields them from the harsh acidic environment of the stomach. This is different from regular probiotics like Lactobacillus, which are more vulnerable to stomach acid. The spore shell remains intact until the bacteria reach the more favorable environment of the intestines, where they then germinate and become active.

Are spore probiotics better than regular probiotics?

'Better' depends on your specific needs. Spore probiotics offer advantages in shelf stability and stomach acid survival. They can be taken with antibiotics. Regular probiotics have a longer research history and more strain-specific evidence for certain conditions. Some people benefit from using both types. There is no universal 'best' probiotic. Your ideal choice depends on your health goals, any specific conditions, and your healthcare provider's recommendations.

Can spore probiotics cause bloating?

Temporary bloating is common during the first 2-3 days of starting spore probiotics. This is often described as a 'die-off' reaction as the gut microbiome adjusts. However, studies suggest that spore probiotics actually help reduce bloating in people with functional bloating over time. To minimize initial bloating, start with a low dose, take with food, stay hydrated, and gradually increase over 2-3 weeks.

Are soil-based probiotics the same as spore probiotics?

Soil-based organisms (SBOs) and spore-based probiotics overlap but are not identical terms. Spore-based probiotics specifically refer to bacteria (primarily Bacillus species) that form protective spores. Soil-based organisms is a broader category that includes spore-forming bacteria plus other organisms found in soil. In practice, most 'soil-based probiotic' products contain Bacillus strains and are functionally similar to spore-based probiotics. The terms are often used interchangeably in the supplement market.

Can spore probiotics help with leaky gut?

Early research suggests spore-based probiotics may help support the gut's protective barrier. The theory is that the short-chain fatty acids produced by Bacillus bacteria, particularly butyrate, help nourish the cells lining the intestines. However, 'leaky gut' (increased intestinal permeability) is still an evolving area of research. Clinical trials specifically targeting leaky gut with spore probiotics are limited. Consult a healthcare provider for evidence-based approaches to gut barrier support.

Our Accuracy Commitment and Editorial Principles

At Biochron, we take health information seriously. Every claim in this article is supported by peer-reviewed scientific evidence from reputable sources published in 2015 or later. We use a rigorous evidence-grading system to help you understand the strength of research behind each statement:


  • [Evidence: A] = Systematic review or meta-analysis (strongest evidence)
  • [Evidence: B] = Randomized controlled trial (RCT)
  • [Evidence: C] = Cohort or case-control study
  • [Evidence: D] = Expert opinion or clinical guideline

Our editorial team follows strict guidelines: we never exaggerate health claims, we clearly distinguish between correlation and causation, we update content regularly as new research emerges, and we transparently note when evidence is limited or conflicting. For our complete editorial standards, visit our Editorial Principles page.


This article is for informational purposes only and does not constitute medical advice. Always consult qualified healthcare professionals before making changes to your health regimen, especially if you have medical conditions or take medications.

References

  1. 1 . A Comprehensive Review and Meta-analysis on the Treatment of Acute Gastroenteritis in Children with a Bacillus clausii Preparation (Enterogermina®), Advances in therapy, 2025, DOI | PubMed [Evidence: A]
  2. 2 . Treatment with a spore-based probiotic containing five strains of Bacillus induced changes in the metabolic activity and community composition of the gut microbiota in a SHIME® model, Food research international, 2021, DOI | PubMed [Evidence: B]
  3. 3 . High-dose multi-strain Bacillus probiotics enhance treatment and reduce antibiotic usage in children with persistent diarrhea, Scientific reports, 2025, DOI | PubMed [Evidence: B]
  4. 4 . Genomic and Phenotypic Safety Assessment of Probiotic Bacillus coagulans Strain JBI-YZ6.3, Probiotics and antimicrobial proteins, 2025, DOI | PubMed [Evidence: B]
  5. 5 . Bacillus spore-forming probiotics: benefits with concerns?, Critical reviews in microbiology, 2022, DOI | PubMed [Evidence: D]
  6. 6 . Effectiveness of Bacillus clausii (O/C, N/R, SIN, T) in the Prevention of Antibiotic-Associated Diarrhea and Gastrointestinal Symptoms: A Systematic Review, Antibiotics, 2025, DOI | PubMed [Evidence: A]
  7. 7 . Nasal-spraying Bacillus spore probiotics for pneumonia in children with respiratory syncytial virus and bacterial co-infections, Communications medicine, 2025, DOI | PubMed [Evidence: B]
  8. 8 . Secondary Metabolites from Bacillus spp. probiotics as potential treatments for multidrug-resistant pathogens, Current research in microbial sciences, 2025, DOI | PubMed [Evidence: D]
  9. 9 . The Efficacy and Safety of Single-Strain Probiotic Formulations Containing Bifidobacterium lactis or Bacillus coagulans in Adult Patients with Irritable Bowel Syndrome, Journal of clinical medicine, 2023, DOI | PubMed [Evidence: B]
  10. 10 . Safety assessment of Bacillus subtilis CU1 for use as a probiotic in humans, Regulatory toxicology and pharmacology, 2017, DOI | PubMed [Evidence: C]
  11. 11 . Safety Assessment of Bacillus subtilis MB40 for Use in Foods and Dietary Supplements, Nutrients, 2021, DOI | PubMed [Evidence: C]
  12. 12 . Effect of Bacillus subtilis ATCC 122264 on intestinal gas symptoms and quality of life in adults with functional bloating, Beneficial microbes, 2025, DOI | PubMed [Evidence: B]
  13. 13 . Therapeutic efficacy of probiotic Alkalihalobacillus clausii 088AE in antibiotic-associated diarrhea, Heliyon, 2021, DOI | PubMed [Evidence: B]

Medical Disclaimer


This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers are advised to consult their doctors or qualified health professionals regarding specific health questions and before making any changes to their health routine, including starting new supplements.

Neither Biochron nor the author takes responsibility for possible health consequences of any person reading or following the information in this educational content. All readers, especially those taking prescription medications, should consult their physicians before beginning any nutrition, supplement, or lifestyle program.

If you have a medical emergency, call your doctor or emergency services immediately.