💡 What You Need to Know Right Away
- Immune System Activation: A randomized controlled trial with 40 multiple myeloma patients found that Agaricus blazei extract increased regulatory T cells and plasmacytoid dendritic cells while elevating key immune cytokines (IL-1ra, IL-5, IL-7).[Evidence: B][6]
- Inflammatory Bowel Disease Relief: In a clinical trial with 50 ulcerative colitis patients, those taking Agaricus blazei extract showed significant symptom improvement by day 21 with reduced fatigue and improved quality of life—with no adverse effects reported.[Evidence: B][7]
- Allergy Symptom Reduction: A study of 60 birch pollen allergy sufferers demonstrated that 7 weeks of supplementation significantly reduced general allergy and asthma symptoms while lowering specific IgE antibody levels.[Evidence: B][11]
- Antitumor Mechanisms: Research indicates that Agaricus blazei works through multiple anticancer pathways including inducing apoptosis (programmed cell death), suppressing metastasis, and inhibiting tumor blood vessel formation.[Evidence: D][3]
You've likely heard about medicinal mushrooms for immune support, but one species stands out for its remarkable research profile: Agaricus blazei, also known as Himematsutake in Japan or Cogumelo do Sol ("Sun Mushroom") in its native Brazil.
With the functional mushroom market predicted to reach USD 34.3 billion by 2025 and post-pandemic demand for immune support at an all-time high, it's no surprise that health-conscious consumers are searching for evidence-based information about this fascinating fungus.
But does Agaricus blazei actually live up to the hype? In this comprehensive guide, we've analyzed 11 peer-reviewed studies published between 2015 and 2025 to bring you the most current, science-backed understanding of this medicinal mushroom's benefits, proper dosage, and important safety considerations. Whether you're managing inflammation, looking for immune support, or curious about natural allergy relief, you'll find answers grounded in clinical research.
❓ Quick Answers
What is Agaricus blazei good for?
Agaricus blazei is primarily used for immune system support, reducing inflammation in digestive conditions, and alleviating allergy symptoms. Clinical trials demonstrate benefits for patients with inflammatory bowel disease (Crohn's and ulcerative colitis) and seasonal allergies. The mushroom contains beta-glucan polysaccharides that activate immune cells and regulate inflammatory responses.[Evidence: B][7]
Is Agaricus blazei safe?
For most healthy adults, Agaricus blazei appears safe when taken at studied doses (60 ml daily extract) for periods up to 7 weeks. Multiple clinical trials report no adverse effects in participants.[Evidence: B][7] However, individuals with liver conditions should consult healthcare providers first, as isolated case reports of liver issues exist in the literature. Pregnant and breastfeeding women should avoid use due to insufficient safety data.
Does Agaricus blazei boost the immune system?
Yes, clinical evidence supports immune-boosting effects. In a randomized trial of 40 multiple myeloma patients, Agaricus blazei extract increased regulatory T cells, plasmacytoid dendritic cells, and elevated immune-signaling molecules including IL-1ra, IL-5, and IL-7. The extract also upregulated genes involved in immunoglobulin production and NK (natural killer) cell receptors.[Evidence: B][6]
How much Agaricus blazei should I take?
Human clinical trials consistently used 60 ml daily of AndoSan™ liquid extract (containing 82.4% Agaricus blazei). This dosage was administered once daily for periods ranging from 21 days to 7 weeks, depending on the health condition being studied. No human trial data exists for powder or capsule forms.[Evidence: B][6][7]
Can Agaricus blazei help with allergies?
Research suggests yes. A randomized clinical trial with 60 birch pollen allergy sufferers found that taking Agaricus blazei extract for 7 weeks before pollen season significantly reduced general allergy and asthma symptoms. Participants also showed lower specific IgE antibody levels and reduced basophil sensitivity—key markers of allergic response.[Evidence: B][11]
🔬 How Does Agaricus Blazei Work?
Understanding how Agaricus blazei works in your body helps explain why it shows such diverse health benefits. Think of beta-glucans—the mushroom's primary active compounds—as molecular keys that unlock your immune system's communication network. When you consume Agaricus blazei, these polysaccharides bind to specific receptors (particularly Dectin-1) on immune cells, essentially "waking up" your body's defense system.
Researchers have identified 126 distinct chemical components in Agaricus blazei, with 45 confirmed as biologically active compounds.[Evidence: C][1] These fall into three main categories: hydrophilic small molecules (including phenolic compounds like gallic acid and syringic acid), lipophilic compounds (ergosterol and fatty acids), and macromolecules (the immunologically important beta-glucans and mannogalactans).[Evidence: D][2]
Immune Modulation Pathways
The immune effects operate through multiple mechanisms. Imagine your immune system as an orchestra—Agaricus blazei acts like a skilled conductor, ensuring all sections play in harmony. In patients with inflammatory bowel disease, the extract reduced pro-inflammatory cytokines including IL-2, IL-1β, IL-6, and G-CSF, while potentially activating alternative anti-inflammatory pathways.[Evidence: B][8]
For cancer-related mechanisms, preclinical research reveals that Agaricus blazei polysaccharides promote CD8+ T cell activity and enhance the cancer-killing capacity of immune cells. One study found these effects were most pronounced when administered as a preventive intervention, altering the tumor microenvironment by increasing omega-3 polyunsaturated fatty acids.[Evidence: C][9]
Antitumor Mechanisms
The anticancer properties work through both direct and indirect pathways. Direct effects include inducing apoptosis (programmed cell death) in tumor cells and suppressing metastasis. Indirect effects involve inhibiting tumor neovascularization—the formation of new blood vessels that tumors need to grow.[Evidence: D][3] In laboratory studies on chronic myeloid leukemia cells, a specific compound (FA-2-b-β) was shown to suppress the PI3K/AKT signaling pathway, which is often overactive in cancer cells.[Evidence: C][1]
Interestingly, the anticancer efficacy appears to be age-dependent. Mouse studies demonstrated that Agaricus blazei polysaccharides were more effective in younger animals (8 months) compared to older ones (12 months), with the mechanism involving lipid reduction in the tumor microenvironment and no toxic side effects observed.[Evidence: C][4]
📊 Dosage and How to Use
All human clinical trials on Agaricus blazei to date have used a standardized liquid extract called AndoSan™, which contains 82.4% Agaricus blazei Murrill, 14.7% Hericium erinaceus (Lion's Mane), and 2.9% Grifola frondosa (Maitake). This is important context because we cannot assume that other forms (powders, capsules, teas) would produce identical results.
| Purpose/Condition | Dosage | Duration | Evidence |
|---|---|---|---|
| Immune support during cancer treatment (multiple myeloma) | 60 ml once daily | 7 weeks | [B][6] |
| Ulcerative colitis symptom management | 60 ml once daily | 21 days | [B][7] |
| Crohn's disease symptom management | 60 ml once daily | 21 days | [B][10] |
| Inflammatory biomarker reduction (IBD) | 60 ml once daily | 21 days | [B][8] |
| Seasonal allergy prevention (birch pollen) | 60 ml once daily | 7 weeks (pre-season) | [B][11] |
Important Dosage Considerations
- Timing: Studies administered the extract once daily; specific timing (morning vs. evening, with or without food) was not specified as a critical factor.
- Consistency: Benefits were observed with consistent daily use over the study periods (21 days to 7 weeks).
- Extract specificity: The AndoSan™ extract is produced by ACE Ltd., Japan, and distributed by Immunopharma AS, Norway. It is registered as a food product in Japan, EU, and Norway.
- Data limitation: No human clinical trial data exists for Agaricus blazei powder, capsules, or teas. Dosage recommendations for these forms would be extrapolated, not evidence-based.
⚠️ Risks, Side Effects, and Warnings
Agaritine: A Compound Requiring Awareness
Agaritine is a hydrazine derivative naturally present in Agaricus species mushrooms. Early toxicology research raised theoretical concerns about its genotoxic potential. However, the compound breaks down significantly during cooking and processing. The levels found in commercially available Agaricus blazei extracts have not been associated with adverse effects in the clinical trials reviewed.[Evidence: D][2][5]
🥗 Practical Ways to Use Agaricus Blazei
Based on the clinical evidence available, here are practical recommendations for incorporating Agaricus blazei into your wellness routine:
1. Choose Verified Extract Products
Since all human clinical data comes from standardized extracts (specifically AndoSan™), look for products that specify their extraction method and polysaccharide content. Fruiting body extracts are preferred over mycelium-based products, as most research uses fruiting body preparations. Third-party testing for heavy metals and contaminants is essential for any mushroom supplement.
2. Time Your Supplementation Strategically
For allergy support, the clinical trial began supplementation 7 weeks before the anticipated pollen season, suggesting that preventive timing may be important.[Evidence: B][11] For immune support during illness or treatment, consistent daily use appears to be the pattern associated with benefits in studies.
3. Consider Combination Products Thoughtfully
The AndoSan™ extract used in trials contains Lion's Mane and Maitake mushrooms in addition to Agaricus blazei. While this means we cannot isolate effects to Agaricus blazei alone, it suggests that mushroom combinations may work synergistically. If using a pure Agaricus blazei product, results may differ from published research.
4. Monitor and Document Your Response
Keep a simple log of any symptoms you're tracking (allergy symptoms, digestive comfort, energy levels) before and during supplementation. This helps you and your healthcare provider assess whether the supplement is providing benefit. In clinical trials, improvements in ulcerative colitis symptoms were notable by day 21.[Evidence: B][7]
⚖️ Agaricus Blazei vs. Other Medicinal Mushrooms
Agaricus blazei belongs to a family of medicinal basidiomycete mushrooms that share some properties but have distinct research profiles. Here's how it compares to other popular options:
| Feature | Agaricus Blazei (ABM) | Lion's Mane | Maitake |
|---|---|---|---|
| Primary Active Compounds | β-glucans, ergosterol, phenolic acids, agaritine | Hericenones, erinacines | β-glucans (D-fraction), polysaccharides |
| Primary Researched Benefits | Immune modulation, anti-inflammatory (IBD), allergy reduction | Cognitive function, nerve growth factor stimulation | Immune support, blood sugar regulation |
| Human Clinical Trials (2015+) | 5 RCTs identified | Limited recent RCTs | Limited recent RCTs |
| Unique Feature | Highest β-glucan content among Agaricus species; studied in cancer supportive care | Only mushroom with NGF-stimulating compounds | D-fraction polysaccharide patented for immune effects |
| Traditional Use Origin | Brazil (folk medicine), Japan (since 1980s) | China, Japan (traditional medicine) | Japan, North America (culinary and medicinal) |
One comprehensive review examined antitumor, anti-inflammatory, and antiallergic effects across Agaricus blazei, Hericium erinaceus (Lion's Mane), and Grifola frondosa (Maitake), noting that while all three demonstrate immunomodulating properties through β-glucan activation of dectin-1 receptors, their specific clinical applications may differ based on their unique compound profiles.[Evidence: D][3]
Agaricus blazei stands out for its specific research in inflammatory bowel disease and seasonal allergies—conditions where other medicinal mushrooms have less clinical data. The bioactive compound profile includes polysaccharides, lipids (ergosterol, sterols), proteins, vitamins B, C, and D, and phenolic compounds that collectively support immunoregulation, anti-inflammatory, hepatoprotective, and antibacterial properties.[Evidence: D][5]
Frequently Asked Questions
What are the side effects of Agaricus blazei?
In the clinical trials reviewed (involving over 200 participants across multiple studies), no adverse effects were reported at the standard dose of 60 ml daily extract for periods up to 7 weeks. However, case reports in the broader medical literature describe isolated incidents of drug-induced liver injury (DILI) in some individuals, particularly those with advanced cancer. These cases showed liver enzyme elevations that resolved after discontinuing the supplement. The compound agaritine, naturally present in Agaricus species, has been studied for potential genotoxicity, though levels in processed extracts are significantly reduced and no clinical adverse events have been attributed to it in controlled studies.
Can Agaricus blazei help with cancer?
Agaricus blazei has been extensively studied for potential anticancer properties, but it's crucial to understand the evidence hierarchy. Preclinical research (laboratory and animal studies) demonstrates multiple anticancer mechanisms: direct tumor cell killing through apoptosis, suppression of metastasis, inhibition of tumor blood vessel formation, and activation of immune cells including CD8+ T cells and NK cells. One human RCT in multiple myeloma patients showed immune-boosting effects but no significant difference in clinical outcomes (p=0.47). Currently, Agaricus blazei is considered a complementary approach—potentially supporting immune function during conventional cancer treatment—not a replacement for standard oncology care. Always discuss with your oncologist before adding any supplement to your regimen.
Is Agaricus blazei good for diabetes?
Comprehensive reviews identify anti-diabetic properties among the health-promoting effects of Agaricus blazei, including potential effects on insulin resistance. However, in our review of 2015-2025 literature, we did not identify any human randomized controlled trials specifically testing Agaricus blazei for diabetes management or blood sugar control. The mechanisms are not fully clarified, and more human clinical evidence is needed before making specific recommendations for diabetic patients. If you have diabetes and are considering Agaricus blazei, discuss with your healthcare provider, especially if you take blood sugar-lowering medications, as supplement-drug interactions could theoretically affect glucose levels.
What is the difference between Agaricus blazei and other mushrooms?
Agaricus blazei (also called ABM, Himematsutake, or Cogumelo do Sol) is taxonomically Agaricus subrufescens—distinct from Agaricus bisporus, the common button mushroom. Key differences include: (1) Compound profile—ABM has exceptionally high β-glucan content compared to other Agaricus species, along with unique phenolic acids and ergosterol; (2) Research focus—ABM has specific clinical data for inflammatory bowel disease and allergies, whereas Lion's Mane specializes in cognitive/nerve effects and Reishi in adaptogenic/sleep support; (3) Traditional context—ABM comes from Brazilian folk medicine and Japanese functional food traditions rather than Chinese medicine; (4) Active mechanisms—while all medicinal mushrooms contain β-glucans, ABM's specific polysaccharide structures appear particularly effective at modulating Th1/Th2 immune balance for allergy relief.
Does Agaricus blazei cause liver damage?
This is an important safety question that requires a nuanced answer. In controlled clinical trials (5 RCTs with over 200 participants), no liver-related adverse events were reported. However, case reports in the medical literature describe isolated incidents of drug-induced liver injury (DILI) in individuals taking Agaricus blazei products, some resembling autoimmune hepatitis histologically. These cases appear more common in patients with advanced cancer, though causality is difficult to establish given these patients' complex medical situations. Paradoxically, preclinical research has also identified hepatoprotective (liver-protecting) effects. The prudent approach: avoid use if you have existing liver disease, monitor for symptoms (jaundice, dark urine, upper abdominal pain), and always disclose supplement use to your healthcare provider.
What are beta-glucans in Agaricus blazei?
Beta-glucans (β-glucans) are the primary bioactive polysaccharides in Agaricus blazei responsible for most of its immune-modulating effects. Chemically, they are complex carbohydrate chains—specifically, glucose polymers with β-1,3 and β-1,6 linkages that create branched structures our immune cells recognize as 'foreign.' When you consume beta-glucans, they bind to Dectin-1 receptors on immune cells (macrophages, dendritic cells, neutrophils), triggering a cascade of immune activation without causing inflammation or illness. This 'trained immunity' effect helps your body respond more effectively to actual threats. Agaricus blazei contains higher concentrations of β-glucans than most other Agaricus species. The mushroom also contains α-glucans, though these are less immunologically active and are sometimes considered a marker of lower-quality extracts (mycelium-heavy products tend to have higher α-glucan ratios).
Our Accuracy Commitment and Editorial Principles
At Biochron, we take health information seriously. Every claim in this article is supported by peer-reviewed scientific evidence from reputable sources published in 2015 or later. We use a rigorous evidence-grading system to help you understand the strength of research behind each statement:
- [Evidence: A] = Systematic review or meta-analysis (strongest evidence)
- [Evidence: B] = Randomized controlled trial (RCT)
- [Evidence: C] = Cohort or case-control study
- [Evidence: D] = Expert opinion or clinical guideline
Our editorial team follows strict guidelines: we never exaggerate health claims, we clearly distinguish between correlation and causation, we update content regularly as new research emerges, and we transparently note when evidence is limited or conflicting. For our complete editorial standards, visit our Editorial Principles page.
This article is for informational purposes only and does not constitute medical advice. Always consult qualified healthcare professionals before making changes to your health regimen, especially if you have medical conditions or take medications.
References
- 1 . Network Pharmacology and In Vitro Experiments Reveal the Mechanism of Agaricus blazei Murill Extract in Treating Chronic Myeloid Leukemia. Wang D, Zhu H, Ge W, Sun Y. Chemistry & Biodiversity, 2025. PubMed | DOI [Evidence: C]
- 2 . Agaricus blazei Bioactive Compounds and their Effects on Human Health: Benefits and Controversies. Souza ACDS, Correa VG, Goncalves GA, et al. Current Pharmaceutical Design, 2017. PubMed | DOI [Evidence: D]
- 3 . Antitumor, Anti-Inflammatory and Antiallergic Effects of Agaricus blazei Mushroom Extract and the Related Medicinal Basidiomycetes Mushrooms, Hericium erinaceus and Grifola frondosa: A Review of Preclinical and Clinical Studies. Hetland G, Tangen JM, Mahmood F, et al. Nutrients, 2020. PubMed | DOI [Evidence: D]
- 4 . The Age-Dependent Anticancer Efficacy of Agaricus blazei Murill Polysaccharide in Colon Cancer. Xu Y, Xu T, Huang C, et al. Molecular Nutrition & Food Research, 2025. PubMed | DOI [Evidence: C]
- 5 . Critical review on chemical compositions and health-promoting effects of mushroom Agaricus blazei Murill. Huang K, El-Seedi HR, Xu B. Current Research in Food Science, 2022. PubMed | DOI [Evidence: D]
- 6 . Immunomodulatory effects of the Agaricus blazei Murrill-based mushroom extract AndoSan in patients with multiple myeloma undergoing high dose chemotherapy and autologous stem cell transplantation: a randomized, double blinded clinical study. Tangen JM, Tierens A, Caers J, et al. BioMed Research International, 2015. PubMed | DOI [Evidence: B]
- 7 . Effect of a Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan™, on Symptoms, Fatigue and Quality of Life in Patients with Ulcerative Colitis in a Randomized Single-Blinded Placebo Controlled Study. Therkelsen SP, Hetland G, Lyberg T, et al. PLoS One, 2016. PubMed | DOI [Evidence: B]
- 8 . Cytokine Levels After Consumption of a Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan™, in Patients with Crohn's Disease and Ulcerative Colitis in a Randomized Single-Blinded Placebo-Controlled Study. Therkelsen SP, Hetland G, Lyberg T, et al. Scandinavian Journal of Immunology, 2016. PubMed | DOI [Evidence: B]
- 9 . Preventive intervention with Agaricus blazei murill polysaccharide exerts anti-tumor immune effect on intraperitoneal metastasis colorectal cancer. Xu Y, Xu T, Huang C, et al. International Journal of Biological Macromolecules, 2024. PubMed | DOI [Evidence: C]
- 10 . Effect of the Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSanTM, on Symptoms, Fatigue and Quality of Life in Patients with Crohn's Disease in a Randomized Single-Blinded Placebo Controlled Study. Therkelsen SP, Hetland G, Lyberg T, et al. PLoS One, 2016. PubMed | DOI [Evidence: B]
- 11 . Agaricus blazei-Based Mushroom Extract Supplementation to Birch Allergic Blood Donors: A Randomized Clinical Trial. Mahmood F, Hetland G, Nentwich I, et al. Nutrients, 2019. PubMed | DOI [Evidence: B]
Medical Disclaimer
This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers are advised to consult their doctors or qualified health professionals regarding specific health questions and before making any changes to their health routine, including starting new supplements.
Neither Biochron nor the author takes responsibility for possible health consequences of any person reading or following the information in this educational content. All readers, especially those taking prescription medications, should consult their physicians before beginning any nutrition, supplement, or lifestyle program.
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