💡 What You Need to Know Right Away
- Reduces stress and anxiety: A meta-analysis of 9 RCTs with 558 participants found significant reductions in perceived stress (MD=-4.72) and serum cortisol levels (MD=-2.58)[Evidence: A][3]
- Improves mental health symptoms: Analysis of 14 RCTs showed Withania somnifera improved anxiety, depression, stress, and sleep quality in individuals with mental disorders[Evidence: A][1]
- Enhances sleep quality: Five RCTs with 400 participants demonstrated significant sleep improvement at doses of 600mg or more daily for 8 weeks or longer[Evidence: A][7]
- Boosts physical performance: A Bayesian meta-analysis of 13 clinical trials found improvements in strength, power, cardiorespiratory fitness, and recovery[Evidence: A][4]
Are you struggling with chronic stress, poor sleep, or anxiety that affects your daily life? You're not alone. Millions of people are turning to natural remedies to support their mental and physical well-being. Withania somnifera, commonly known as ashwagandha, has emerged as one of the most researched adaptogenic herbs with a growing body of clinical evidence.
This ancient Ayurvedic herb has been used for over 3,000 years in traditional Indian medicine. Today, modern science is validating what traditional practitioners have known for centuries. With 8 systematic reviews and meta-analyses examining its effects on stress, anxiety, sleep, cognitive function, and physical performance, Withania somnifera stands out as one of the most evidence-backed adaptogens available.
In this comprehensive guide, you'll discover the science behind Withania somnifera's benefits, evidence-based dosage recommendations, safety considerations, and practical tips for incorporating this powerful herb into your wellness routine. Every claim is backed by peer-reviewed research so you can make informed decisions about your health.
❓ Quick Answers
What is Withania somnifera used for?
Withania somnifera (ashwagandha) is an adaptogenic herb used primarily for stress reduction, anxiety relief, and sleep improvement. Clinical research shows it effectively reduces perceived stress scores and cortisol levels while improving mental health symptoms including depression and anxiety.[Evidence: A][3]
Is ashwagandha safe to take daily?
Research indicates Withania somnifera is safe for daily use in short-term studies up to 3 months. A 12-month observational study reported only 18 mild adverse events with no significant hematological or biochemical changes. Most adverse effects are mild and transient, including somnolence and digestive discomfort.[Evidence: A][1]
What are the side effects of ashwagandha?
The most common side effects include somnolence (drowsiness), epigastric pain or discomfort, and loose stools, each occurring in more than 5% of users. These effects are typically mild and transient. No serious adverse events were reported in clinical trials examining mental health applications.[Evidence: A][2]
Does ashwagandha help with anxiety?
Yes. A meta-analysis of 5 RCTs with 254 participants found significant reductions in Hamilton Anxiety Rating Scale (HAM-A) scores. Another study in patients with generalized anxiety disorder showed HAM-A score reductions of 14 units with treatment versus 8 units with placebo.[Evidence: A][2][10]
Does ashwagandha help you sleep?
Research confirms Withania somnifera improves sleep quality. A meta-analysis of 5 RCTs with 400 participants showed significant sleep improvement, including better sleep onset latency, total sleep time, and overall sleep quality. Effects are most pronounced at doses of 600mg daily or higher for 8 weeks or longer.[Evidence: A][7]
How much ashwagandha should I take daily?
Clinical studies show effective doses range from 125mg to 1000mg daily depending on the intended benefit. For stress and anxiety, 300-600mg daily is commonly used. For sleep improvement, research supports 600mg daily. Doses are typically taken for 6-8 weeks to observe effects.[Evidence: A][3][7]
How long does ashwagandha take to work?
Clinical trials typically demonstrate effects within 6-8 weeks of consistent use. A study on chronic stress showed measurable improvements at 8 weeks with doses as low as 125mg daily. For sleep benefits, significant improvements were observed after 8 weeks at 600mg daily.[Evidence: B][9]
🔬 How Does Withania Somnifera Work?
Think of Withania somnifera as a skilled thermostat for your body's stress response system. Just as a thermostat senses temperature changes and adjusts heating or cooling to maintain balance, this adaptogenic herb helps regulate your hypothalamic-pituitary-adrenal (HPA) axis—the command center that controls how your body responds to stress.[Evidence: B][9]
When you experience stress, your HPA axis triggers the release of cortisol, the primary stress hormone. Chronically elevated cortisol can lead to anxiety, sleep problems, and mental fatigue. Withania somnifera works by modulating this stress response, helping to reduce serum cortisol levels. Research demonstrates a mean difference reduction of -2.58 in cortisol levels compared to placebo.[Evidence: A][3]
The herb's active compounds, called withanolides (including Withaferin A and Withanolide A), appear to work through multiple pathways. These steroidal lactones interact with GABA receptors in the brain, which may explain the calming and anxiolytic effects observed in clinical studies. GABA is the brain's primary inhibitory neurotransmitter, helping to reduce neuronal excitability and promote relaxation.
Beyond stress modulation, Withania somnifera demonstrates effects on inflammation through the NF-κB pathway. Like a guard that controls which signals get through to cause inflammation, the herb's compounds appear to regulate this critical inflammatory pathway. This multi-target mechanism helps explain why Withania somnifera shows benefits across diverse health outcomes including mental health, physical performance, and metabolic function.[Evidence: A][1]
The dose-dependent nature of these effects is important to understand. Research shows that even low doses (125mg daily) can produce clinically meaningful stress reduction, with effects strengthening at higher doses of 250mg and 500mg daily. This suggests a graduated response where you can start low and adjust based on your individual needs.[Evidence: B][9]
📊 Dosage and How to Use
Determining the right dosage of Withania somnifera depends on your specific health goals. Clinical trials have established effective dose ranges for different applications, all using standardized extracts with verified withanolide content.
| Purpose/Condition | Dosage | Duration | Evidence |
|---|---|---|---|
| Mental health improvement (anxiety, depression, stress) | 600 mg/day | 8 weeks | [A][1] |
| Stress and anxiety reduction | 300-600 mg/day | Variable (typically 6-8 weeks) | [A][3] |
| Sleep improvement | 600 mg/day | 8 weeks or longer | [A][7] |
| Chronic stress management (low dose) | 125 mg/day | 8 weeks | [B][9] |
| Chronic stress management (moderate dose) | 250-500 mg/day | 8 weeks | [B][9] |
| Generalized anxiety disorder (adjunctive with SSRIs) | 1000 mg/day | 6 weeks | [B][10] |
| Anxiety symptoms (HAM-A reduction) | 300-600 mg/day | 6-8 weeks | [A][2] |
Important Dosage Considerations
- Starting dose: Consider beginning with 125-300mg daily and gradually increasing based on response and tolerance
- Timing: For sleep benefits, take in the evening; for stress/energy support, morning or divided doses may be preferred
- Consistency: Effects typically require 6-8 weeks of consistent daily use to become apparent
- Maximum validated dose: The highest dose studied in RCTs was 1000mg daily for GAD patients as adjunctive therapy[Evidence: B][10]
⚠️ Risks, Side Effects, and Warnings
Side Effects by Frequency
Clinical studies report the following adverse events. Most effects are mild and transient:[Evidence: A][2]
- Common (>5%): Somnolence (drowsiness), epigastric discomfort or pain, loose stools
- Uncommon: Nausea, headache, upper respiratory symptoms
- Serious adverse events: None reported in clinical trials examining mental health applications[Evidence: A][1]
Drug Interactions
- CYP450 substrates: In vitro studies show no significant CYP450 inhibition (IC50 >100 μg/mL), suggesting low interaction potential with medications metabolized by these enzymes
- Digoxin: Withania somnifera components may interfere with digoxin immunoassay measurements, potentially causing falsely elevated readings
- Blood thinners (anticoagulants/antiplatelets): CONTRAINDICATED - Withaferin A has demonstrated anticoagulant and antiplatelet activity
- Sedatives and CNS depressants: May cause additive CNS depression and increased somnolence risk
- Thyroid medications: May affect thyroid function; monitor thyroid levels if taking thyroid medications
Contraindications
- Pregnancy: AVOID - Insufficient safety data; traditional use suggests potential abortifacient effects
- Lactation: AVOID - No safety data available for breastfeeding women
- Autoimmune disorders: Use with caution due to immunomodulatory effects
- Upcoming surgery: Discontinue at least 2 weeks before scheduled surgery due to potential effects on anesthesia and bleeding
- Thyroid disorders: May affect thyroid hormone levels; consult healthcare provider
Monitoring Recommendations
- Initial period (first 2-4 weeks): Monitor for drowsiness, digestive discomfort, and any allergic reactions
- Ongoing use: If taking thyroid medications, periodic thyroid function tests are advisable
- Stop immediately if: You experience severe drowsiness, significant gastrointestinal distress, signs of allergic reaction, or unusual bleeding
🥗 Practical Ways to Use Withania Somnifera
How to Use This in Your Daily Life
Scenario 1: Stress and Anxiety Management
- Dose: 300-600mg daily[3]
- Duration: 6-8 weeks for initial assessment
- Population: Adults experiencing moderate stress or anxiety
- Timing: Morning dose or split between morning and evening
- What to track: Perceived Stress Scale (PSS) scores, anxiety symptoms, cortisol-related symptoms
- Expected results: Significant reduction in PSS scores (MD=-4.72) and anxiety scale scores (MD=-2.19)[3]
Scenario 2: Sleep Improvement
- Dose: 600mg daily[7]
- Duration: 8 weeks or longer
- Population: Adults with insomnia or poor sleep quality
- Timing: Evening, approximately 1-2 hours before bedtime
- What to track: Sleep onset latency, total sleep time, sleep quality ratings, daytime alertness
- Expected results: Significant improvement in overall sleep quality, enhanced mental alertness on waking[7]
Scenario 3: Starting with Low Dose (Sensitive Individuals)
- Dose: 125mg daily[9]
- Duration: 8 weeks
- Population: Chronically stressed adults, those new to adaptogens, or sensitive individuals
- Timing: Morning with breakfast
- What to track: Stress symptoms, tolerability, any side effects
- Expected results: Clinically meaningful stress reduction via HPA axis modulation[9]
Practical Integration
Take your dose with food to minimize any potential digestive discomfort. Capsules should be taken with water. If using powder form, it can be mixed into warm milk (traditional "ashwagandha milk"), smoothies, or other beverages. Store in a cool, dry place away from direct sunlight and heat.
Common Mistakes to Avoid
- Expecting immediate results: Clinical studies demonstrate effects at 6-8 weeks[9]. Adaptogens work gradually; patience is essential.
- Inconsistent dosing: Studies used daily dosing for the full duration. Sporadic use may not achieve the benefits shown in research.
- Taking too late for sleep if stimulating: While Withania somnifera generally promotes calm, some individuals may experience mild activation. Adjust timing based on personal response.
- Ignoring potential interactions: Review the drug interaction section and consult healthcare providers if on medications.
- Using low-quality products: Choose standardized extracts (typically 5%+ withanolides) from reputable manufacturers with third-party testing.
⚖️ Withania Somnifera vs Other Adaptogens
Adaptogens are a class of herbs that help the body resist physical, chemical, and biological stressors. Withania somnifera stands out among adaptogens due to its extensive clinical research base. Here's how it compares to other popular options:
| Feature | Withania Somnifera (Ashwagandha) | Rhodiola Rosea | Panax Ginseng |
|---|---|---|---|
| Primary Effects | Calming, stress reduction, sleep improvement | Energizing, mental performance, fatigue reduction | Energy, cognitive function, immune support |
| Best For | Anxiety, sleep issues, chronic stress | Mental fatigue, physical endurance, focus | Energy, stamina, cognitive support |
| Energy Profile | Calming/neutral | Mildly stimulating | Stimulating |
| Time of Day | Morning or evening | Morning (avoid evening) | Morning (avoid evening) |
| Evidence for Stress/Anxiety | Strong (8 meta-analyses)[1][3] | Moderate | Moderate |
| Evidence for Physical Performance | Strong (meta-analysis of 13 trials)[4] | Moderate | Moderate |
| Sleep Effects | Improves sleep quality[7] | May interfere with sleep if taken late | May interfere with sleep if taken late |
Key Differentiators
Withania somnifera is unique among adaptogens for its calming effects without sedation during the day, making it suitable for both daytime stress management and evening sleep support. Unlike stimulating adaptogens like Rhodiola or Ginseng, ashwagandha is less likely to cause jitteriness or interfere with sleep when taken later in the day.
The research base for Withania somnifera is particularly strong. A Bayesian meta-analysis of 13 clinical trials confirmed its efficacy for physical performance, including improvements in strength, power, and cardiorespiratory fitness.[Evidence: A][4] A separate meta-analysis of 5 studies with 162 participants showed significant VO2max improvement with a mean difference of 3.00 ml/kg/min.[Evidence: A][5]
What The Evidence Shows (And Doesn't Show)
What Research Suggests
The evidence base for Withania somnifera is strong, consisting of 8 systematic reviews/meta-analyses (Level A) and 2 randomized controlled trials (Level B).
- Stress and anxiety reduction is well-established: Meta-analysis of 9 RCTs (n=558) showed significant reductions in Perceived Stress Scale (MD=-4.72), Hamilton Anxiety Scale (MD=-2.19), and serum cortisol (MD=-2.58).[Evidence: A][3]
- Mental health benefits across multiple symptoms: Analysis of 14 RCTs (360 treatment, 353 control) demonstrated improvements in anxiety, depression, stress, and sleep quality at median doses of 600mg daily for 8 weeks.[Evidence: A][1]
- Sleep quality improvement is evidence-based: Meta-analysis of 5 RCTs (n=400) showed significant sleep improvement at ≥600mg/day for ≥8 weeks, including better sleep onset latency and total sleep time.[Evidence: A][7]
- Physical performance enhancement is supported: Bayesian meta-analysis of 13 trials confirmed improvements in strength, power, cardiorespiratory fitness, and recovery; VO2max improved by 3.00 ml/kg/min.[Evidence: A][4][5]
- Blood glucose effects are promising: Meta-analysis of clinical studies showed significant blood glucose reduction (MD -196.27, 95% CI [-220.96, -171.58]) with improved HbA1c, insulin, and lipid profiles.[Evidence: A][6]
What's NOT Yet Proven
- Optimal dosage not definitively established: Studies used doses ranging from 125mg to 1000mg daily with varying results; the ideal dose for different goals remains under investigation
- Long-term safety beyond 12 months unclear: The longest observational safety study was 12 months; effects of multi-year use are unknown
- Specific populations understudied: Children, elderly (>65), pregnant/breastfeeding women, and those with serious medical conditions were excluded from most trials
- Testosterone effects need more research: While physical performance improved, specific hormonal outcomes require dedicated study
- Mechanism details incomplete: While HPA axis modulation and GABA effects are supported, complete understanding of all pathways remains under investigation
Where Caution Is Needed
- Anticoagulant interaction risk: Withaferin A has demonstrated anticoagulant and antiplatelet activity—avoid combining with blood thinners
- Sedative combinations: May cause additive CNS depression when combined with sedatives, benzodiazepines, or alcohol
- Thyroid medication users: May affect thyroid hormone levels, requiring monitoring and potential dose adjustments
- Autoimmune conditions: Immunomodulatory effects may be problematic for those with autoimmune disorders
- Product quality variance: Not all products contain stated withanolide content; choose third-party tested products from reputable manufacturers
Should YOU Try This?
Best suited for: Adults experiencing chronic stress, anxiety, sleep difficulties, or seeking to improve physical performance. Those who have tried lifestyle modifications but need additional support. Individuals looking for evidence-based natural options with strong clinical research backing.
Not recommended for: Pregnant or breastfeeding women. Individuals taking anticoagulants, immunosuppressants, or thyroid medications without medical supervision. Those with autoimmune conditions, scheduled surgery within 2 weeks, or known allergy to nightshade family plants.
Realistic timeline: Based on clinical trials, expect 6-8 weeks of consistent daily use before assessing effects. Some individuals may notice benefits sooner; others may need the full 8 weeks. Low doses (125mg) showed effects at 8 weeks[9]; sleep benefits required 8+ weeks at 600mg daily.[7]
When to consult a professional: Before starting if you take any medications, have thyroid conditions, autoimmune disorders, or chronic health conditions. During use if you experience unusual symptoms, significant drowsiness, digestive issues, or any concerning effects. After 8-12 weeks to assess whether continued use is beneficial for your goals.
Frequently Asked Questions
Who should not take ashwagandha?
Several groups should avoid Withania somnifera or use it only under medical supervision. Pregnant and breastfeeding women should avoid it due to insufficient safety data. Individuals with autoimmune conditions (such as rheumatoid arthritis, lupus, or Hashimoto's thyroiditis) should consult their healthcare provider, as the herb has immunomodulatory effects that could theoretically worsen these conditions. Those taking anticoagulants or antiplatelet medications should avoid use due to Withaferin A's effects on blood clotting. People scheduled for surgery should discontinue use at least 2 weeks before their procedure. Those with thyroid disorders should have their thyroid function monitored, as the herb may affect thyroid hormone levels.
Can ashwagandha damage your liver?
Current clinical evidence does not indicate liver damage risk from Withania somnifera at studied doses. A systematic review examining safety across multiple RCTs reported no serious adverse events, including no hepatotoxicity. A 12-month observational study showed no significant hematological or biochemical changes. However, isolated case reports of liver injury exist in medical literature, though causality has not been definitively established and confounding factors were often present. Those with pre-existing liver conditions should consult their healthcare provider before use. Signs of liver problems include yellowing of skin/eyes, dark urine, unusual fatigue, or abdominal pain—discontinue use and seek medical attention if these occur.
Can ashwagandha increase testosterone?
Research suggests Withania somnifera may support healthy testosterone levels in men, though this was not a primary focus of the verified meta-analyses in this review. The physical performance meta-analysis noted improvements in strength and power that may be partially mediated by hormonal effects. Earlier studies have reported testosterone increases in infertile men and those undergoing resistance training, but specific percentage improvements vary by study. The effect appears more pronounced in men with suboptimal baseline levels. Women should be aware of potential androgenic effects. For testosterone-specific outcomes, consult specialized research or a healthcare provider.
What is the difference between KSM-66 and Sensoril?
KSM-66 and Sensoril are both standardized Withania somnifera extracts but differ in their source material and withanolide concentration. KSM-66 is a full-spectrum extract derived solely from ashwagandha roots, standardized to 5% withanolides. It is one of the most clinically researched forms. Sensoril is extracted from both leaves and roots, typically standardized to a higher withanolide percentage (around 10%). Both have demonstrated efficacy in clinical studies. The clinical trials reviewed here used various standardized extracts including KSM-66.Choice between them may depend on personal response, desired withanolide concentration, and product availability.
Can you take ashwagandha with other medications?
Withania somnifera can be taken with many medications, but certain combinations require caution or should be avoided. It was safely used as adjunctive therapy with SSRIs in patients with generalized anxiety disorder, showing no adverse interactions and improved outcomes. In vitro studies show no significant CYP450 enzyme inhibition, suggesting low metabolic interaction potential. However, avoid combining with anticoagulants/antiplatelets (increased bleeding risk), sedatives (additive CNS depression), and use caution with thyroid medications (may affect thyroid levels). Digoxin users should note potential assay interference. Always inform your healthcare provider of all supplements before combining with prescription medications.
Does ashwagandha affect the thyroid?
Research indicates Withania somnifera may influence thyroid function, though this effect was not the primary focus of the meta-analyses reviewed. Some studies suggest it may support thyroid hormone production, potentially beneficial for subclinical hypothyroidism but potentially problematic for hyperthyroidism. Those with Hashimoto's thyroiditis, Graves' disease, or other thyroid conditions should consult their healthcare provider before use. If you take thyroid medications like levothyroxine, your thyroid levels should be monitored when starting supplementation, as dose adjustments may become necessary. This represents an area where effects may vary significantly by individual thyroid status.
Is ashwagandha safe during pregnancy?
Withania somnifera should be AVOIDED during pregnancy. There is insufficient safety data from clinical trials in pregnant women, and traditional Ayurvedic texts suggest potential abortifacient (pregnancy-terminating) effects. Animal studies have shown mixed results regarding reproductive safety. No clinical trials have specifically evaluated safety in pregnant populations, so the risks are unknown. The same caution applies to breastfeeding, as it is unknown whether components pass into breast milk. Women who are pregnant, planning pregnancy, or breastfeeding should avoid use and consult their healthcare provider about safe alternatives for stress management.
Does ashwagandha reduce cortisol?
Yes, clinical evidence confirms Withania somnifera reduces serum cortisol levels. A meta-analysis of 9 RCTs with 558 participants demonstrated a significant reduction in serum cortisol with a mean difference of -2.58 compared to placebo. This cortisol-lowering effect is one of the primary mechanisms through which the herb reduces perceived stress. The effect occurs through modulation of the HPA axis, the body's central stress response system. This biochemical effect supports the subjective improvements in stress and anxiety symptoms reported across multiple clinical trials.
Can ashwagandha improve athletic performance?
Strong evidence supports Withania somnifera's benefits for physical performance. A Bayesian meta-analysis of 13 clinical trials (12 in quantitative analysis) found it more efficacious than placebo for improving strength, power, cardiorespiratory fitness, and fatigue recovery. A separate meta-analysis of 5 studies with 162 participants demonstrated significant VO2max improvement with a mean difference of 3.00 ml/kg/min (95% CI: 0.18 to 5.82, p=0.04). These effects benefit both trained athletes and healthy adults seeking to improve exercise capacity and recovery.
Does ashwagandha boost immune function?
Withania somnifera demonstrates immunomodulatory effects, though specific immune-boosting outcomes were not the primary focus of the reviewed meta-analyses. The herb contains compounds that influence immune cell activity and inflammatory pathways, including the NF-κB pathway. A systematic review examining diabetes applications noted anti-inflammatory properties among its mechanisms. However, this immunomodulatory nature is also why those with autoimmune conditions should use caution—the herb may stimulate immune activity in ways that could potentially exacerbate autoimmune responses. For primary immune support goals, discuss with your healthcare provider.
Our Accuracy Commitment and Editorial Principles
At Biochron, we take health information seriously. Every claim in this article is supported by peer-reviewed scientific evidence from reputable sources published in 2015 or later. We use a rigorous evidence-grading system to help you understand the strength of research behind each statement:
- [Evidence: A] = Systematic review or meta-analysis (strongest evidence)
- [Evidence: B] = Randomized controlled trial (RCT)
- [Evidence: C] = Cohort or case-control study
- [Evidence: D] = Expert opinion or clinical guideline
Our editorial team follows strict guidelines: we never exaggerate health claims, we clearly distinguish between correlation and causation, we update content regularly as new research emerges, and we transparently note when evidence is limited or conflicting. For our complete editorial standards, visit our Editorial Principles page.
This article is for informational purposes only and does not constitute medical advice. Always consult qualified healthcare professionals before making changes to your health regimen, especially if you have medical conditions or take medications.
References
- 1 . The effect of Withania somnifera (Ashwagandha) on mental health symptoms in individuals with mental disorders: systematic review and meta-analysis, Marchi M, et al., BJPsych Open, 2025; 11(6):e260. PubMed | DOI [Evidence: A]
- 2 . Safety and efficacy of Withania somnifera for anxiety and insomnia: Systematic review and meta-analysis, Fatima K, et al., Human Psychopharmacology, 2024; 39(6):e2911. PubMed | DOI [Evidence: A]
- 3 . Effects of Ashwagandha (Withania Somnifera) on stress and anxiety: A systematic review and meta-analysis, Arumugam V, et al., Explore (NY), 2024; 20(6):103062. PubMed | DOI [Evidence: A]
- 4 . Effects of Ashwagandha (Withania somnifera) on Physical Performance: Systematic Review and Bayesian Meta-Analysis, Bonilla DA, et al., Journal of Functional Morphology and Kinesiology, 2021; 6(1):20. PubMed | DOI [Evidence: A]
- 5 . Effects of Ashwagandha (Withania somnifera) on VO2max: A Systematic Review and Meta-Analysis, Pérez-Gómez J, et al., Nutrients, 2020; 12(4):1119. PubMed | DOI [Evidence: A]
- 6 . Withania somnifera (Indian ginseng) in diabetes mellitus: A systematic review and meta-analysis of scientific evidence from experimental research to clinical application, Durg S, et al., Phytotherapy Research, 2020; 34(5):1041-1059. PubMed | DOI [Evidence: A]
- 7 . Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis, Cheah KL, et al., PLoS One, 2021; 16(9):e0257843. PubMed | DOI [Evidence: A]
- 8 . A systematic review of the clinical use of Withania somnifera (Ashwagandha) to ameliorate cognitive dysfunction, Ng QX, et al., Phytotherapy Research, 2020; 34(3):583-590. PubMed | DOI [Evidence: A]
- 9 . Effects of Withania somnifera Extract in Chronically Stressed Adults: A Randomized Controlled Trial, Pandit S, et al., Nutrients, 2024; 16(9):1293. PubMed | DOI [Evidence: B]
- 10 . Assessment of the Efficacy of Withania somnifera Root Extract in Patients with Generalized Anxiety Disorder: A Randomized Double-blind Placebo-Controlled Trial, Fuladi S, et al., Current Reviews in Clinical and Experimental Pharmacology, 2021; 16(2):191-196. PubMed | DOI [Evidence: B]
Medical Disclaimer
This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers are advised to consult their doctors or qualified health professionals regarding specific health questions and before making any changes to their health routine, including starting new supplements.
Neither Biochron nor the author takes responsibility for possible health consequences of any person reading or following the information in this educational content. All readers, especially those taking prescription medications, should consult their physicians before beginning any nutrition, supplement, or lifestyle program.
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