💡 What You Need to Know Right Away
- Capsaicinoids from red pepper increase your resting metabolic rate by approximately 34 kcal/day, enhancing fat oxidation compared to placebo.[Evidence: A][2]
- L-carnitine supplementation at 2000 mg/day significantly decreases body weight, BMI, and fat mass based on 37 randomized controlled trials involving 2,292 participants.[Evidence: A][12]
- Multi-ingredient thermogenic supplements can increase resting energy expenditure by 121-166 kcal/day within 30-180 minutes after ingestion.[Evidence: B][4]
- Green coffee bean extract containing 500 mg/day of chlorogenic acid lowers body weight by 1.30 kg according to meta-analysis findings.[Evidence: A][14]
You've probably wondered whether thermogenic supplements actually deliver on their promises. With so many products claiming to boost metabolism and accelerate fat loss, separating genuine science from marketing hype can feel overwhelming. You're not alone in this search for clarity.
The global weight loss supplement market continues to grow, projected to reach $45 billion by 2035. But growth doesn't equal effectiveness. What does the research actually say about these metabolism-boosting compounds?
This comprehensive guide examines 27 peer-reviewed studies—including 7 meta-analyses and 18 randomized controlled trials—to give you an honest, evidence-based look at thermogenic supplements. You'll discover which ingredients have scientific backing, appropriate dosages based on clinical research, important safety considerations, and practical guidance for making informed decisions about your health.
Whether you're considering thermogenic supplements for the first time or evaluating your current regimen, this guide provides the scientific foundation you need.
❓ Quick Answers
Do thermogenic supplements really work?
Research confirms thermogenic supplements produce modest but measurable effects. Meta-analyses show capsaicinoids increase metabolic rate by approximately 34 kcal/day, while multi-ingredient formulas can boost energy expenditure by 121-166 kcal/day for several hours post-ingestion.[Evidence: A][2] However, effects are generally smaller than diet and exercise alone.[Evidence: A][1]
Are thermogenic supplements safe?
Short-term use (4-6 weeks) appears safe for healthy adults when following recommended dosages. Studies confirm blood markers remain within physiological ranges during this period.[Evidence: B][6] However, combining synephrine with high-dose caffeine raises hepatotoxicity concerns in laboratory studies.[Evidence: C][23] Consult a healthcare provider before use.
How do thermogenic supplements work?
Thermogenic supplements increase heat production through several mechanisms: stimulating the sympathetic nervous system, activating brown adipose tissue via β3-adrenergic receptors, and enhancing fat oxidation during rest and exercise. Key compounds like caffeine and capsaicin trigger catecholamine release, which accelerates lipolysis and energy expenditure.[Evidence: B][10]
What ingredients are in thermogenic supplements?
Common evidence-backed thermogenic ingredients include caffeine, green tea extract (EGCG), capsaicin from cayenne pepper, p-synephrine from bitter orange, L-carnitine, chlorogenic acid from green coffee, and forskolin from Coleus forskohlii. Multi-ingredient formulations combining these compounds are most common in commercial products.[Evidence: B][5]
When should I take thermogenic supplements?
For optimal fat oxidation effects during exercise, take thermogenic supplements 30-60 minutes before physical activity. Caffeine-containing products should be avoided within 4-6 hours of bedtime to prevent sleep disruption. Studies show metabolic effects peak at 60-180 minutes post-ingestion and can persist for several hours.[Evidence: B][4]
What are the side effects of thermogenic supplements?
Common side effects include jitteriness, increased heart rate, and elevated blood pressure (typically 3-4 mmHg systolic).[Evidence: B][4] Gastrointestinal discomfort may occur with capsaicin-containing products. Serious but rare effects include hepatotoxicity with certain ingredient combinations. Individual sensitivity varies significantly.
🔬 How Do Thermogenic Supplements Work?
Understanding how thermogenic supplements affect your body helps you make informed decisions about their use. At its core, thermogenesis is simply heat production—the metabolic process your body uses to convert calories into thermal energy rather than storing them as fat.
Think of your metabolism as a furnace. Thermogenic supplements don't replace the wood (calories) or do the burning for you—they act like bellows, increasing airflow to make your metabolic fire burn hotter. This enhanced combustion means more calories converted to heat and less stored as fat.
The primary mechanism involves stimulation of your sympathetic nervous system. When you consume compounds like caffeine or capsaicin, they trigger the release of catecholamines—hormones including adrenaline and noradrenaline. These hormones bind to adrenergic receptors on fat cells, initiating lipolysis (fat breakdown) and thermogenesis.[Evidence: B][10]
Research demonstrates that β3-adrenergic receptors play a critical role in activating brown adipose tissue (BAT)—a specialized fat that burns calories to generate heat. Studies using the β3-AR agonist mirabegron confirmed that stimulating these receptors significantly increases both lipolysis and thermogenesis in human brown and beige fat cells.[Evidence: B][10]
Picture brown fat as tiny biological heaters scattered throughout your body. Unlike regular white fat that stores energy, brown fat contains numerous mitochondria that actively burn fuel to produce warmth. Thermogenic compounds essentially turn up these internal heaters.
Caffeine increases metabolism through effects on brown adipose tissue activation and adenosine receptor antagonism, which promotes sustained energy expenditure.[Evidence: D][20] Meanwhile, capsaicinoids work through TRPV1 receptor activation, directly stimulating thermogenesis and increasing resting metabolic rate by approximately 34 kcal/day.[Evidence: A][2]
Single doses of multi-ingredient thermogenic supplements have demonstrated significant increases in resting metabolic rate at 60, 120, and 180 minutes post-ingestion, with effects sustained for several hours.[Evidence: B][26] P-synephrine and caffeine both increase maximal fat oxidation during exercise, though combining them does not produce additive effects.[Evidence: B][21]
📊 Dosage and How to Use
Effective dosing varies by ingredient and intended purpose. The following table summarizes evidence-based dosages from clinical trials and meta-analyses. All values represent what was used in research—individual needs may vary.
| Ingredient/Purpose | Dosage | Frequency/Duration | Evidence |
|---|---|---|---|
| L-Carnitine (weight loss, body composition) | 2000 mg/day | Daily, ongoing | [A][12] |
| Chlorogenic Acid / Green Coffee (body weight) | 500 mg/day | Daily, ≥4 weeks | [A][14] |
| Green Coffee Bean Extract (weight reduction) | 500 mg twice daily | 12 weeks | [B][15] |
| High-CGA Coffee (visceral fat) | 369 mg CGA/serving | Daily, 12 weeks | [B][17] |
| Chlorogenic Acid Isomers (body composition) | 500 mg/day | 12 weeks | [B][18] |
| p-Synephrine (fat oxidation during exercise) | 3 mg/kg body weight | Single dose, pre-exercise | [B][8] |
| L-Carnitine (acute fat oxidation) | 750 mg | Single dose | [B][11] |
| p-Synephrine (resistance exercise) | 100 mg | Single dose, pre-workout | [B][22] |
Important Dosing Considerations
Timing matters. P-synephrine at 3 mg/kg body weight produces the greatest fat oxidation increases when taken before exercise. At this dose, participants achieved maximal fat oxidation rates of 0.55 ± 0.14 g/min compared to 0.35 ± 0.05 g/min with placebo.[Evidence: B][8]
Duration requirements. Meta-analysis data indicates that supplementation for less than 4 weeks typically shows no measurable effect on body composition.[Evidence: A][16] Plan for at least 8-12 weeks of consistent use to evaluate effectiveness.
Individual variation. Response to thermogenic compounds varies based on body weight, caffeine sensitivity, genetic factors, and baseline metabolic rate. Start with lower doses and gradually increase while monitoring for adverse effects.
⚠️ Risks, Side Effects, and Warnings
Cardiovascular Effects
Clinical trials document modest cardiovascular changes with thermogenic supplement use. Mean increases in systolic blood pressure of 3-4 mmHg occur within normal physiological ranges and do not represent adverse responses in healthy adults.[Evidence: B][4] Free fatty acid concentrations increase at 60 and 180 minutes post-ingestion, indicating enhanced fat mobilization.[Evidence: B][4]
Six-week intervention studies confirm thermogenic supplements did not adversely affect safety markers, with blood chemistry results remaining safe throughout the study period.[Evidence: B][5]
Hepatotoxicity Concerns
Laboratory research raises important cautions about ingredient combinations. Synephrine and caffeine at ratios of 3:90 and 3:600 μM—concentrations relevant to human supplement exposure—significantly decreased liver cell viability, increased DNA damage, and triggered programmed cell death pathways.[Evidence: C][23] While these findings are from in vitro studies and clinical translation remains uncertain, they warrant caution regarding long-term combined use.
Short-term safety data (28 days) shows all blood markers, including liver enzymes, remained within accepted physiological ranges for multi-ingredient thermogenic supplements containing caffeine, green tea extract, and cayenne powder.[Evidence: B][6]
Special Populations
| Population | Recommendation | Evidence Level |
|---|---|---|
| Pregnant Women | Caffeine ≤200 mg/day; avoid synephrine-containing products | A |
| Lactating Women | Minimize caffeine; monitor infant for irritability | C |
| Children (<12 years) | Contraindicated; no safe dosages established | A |
| Adolescents (12-18) | ≤2.5 mg caffeine/kg body weight/day | A |
Drug Interactions
Potential interactions have not been fully characterized in clinical trials. Caffeine-containing thermogenic supplements may interact with stimulant medications, certain antidepressants (MAOIs), and medications affecting heart rhythm. Synephrine may interact with monoamine oxidase inhibitors and blood pressure medications. Inform your healthcare provider of all medications before starting thermogenic supplements.
🥗 Practical Ways to Use Thermogenic Supplements
How to Use This in Your Daily Life
Scenario 1: Weight Management with L-Carnitine
- Dose: 2000 mg/day[12]
- Duration: Ongoing; meta-analysis combined data from various trial lengths[12]
- Population: Overweight/obese adults[12]
- Timing: With meals to enhance absorption
- What to track: Body weight, BMI, fat mass
- Expected results: Significant decreases in body weight, BMI, and fat mass[12]
Scenario 2: Green Coffee for Body Composition
- Dose: 500 mg twice daily (1000 mg total)[15]
- Duration: 12 weeks[15]
- Population: Overweight individuals[15]
- Timing: Before meals
- What to track: Body weight, BMI, waist circumference, glucose metabolism
- Expected results: Approximately 6% body weight reduction; ~97% of participants showed measurable weight reduction[15]
Scenario 3: Pre-Exercise Fat Oxidation
- Dose: 750 mg L-carnitine OR 3 mg/kg p-synephrine[11][8]
- Duration: Single dose, acute effects
- Population: Healthy adults
- Timing: 30-60 minutes before exercise
- What to track: Exercise performance, perceived energy, fat oxidation during recovery
- Expected results: Enhanced fat oxidation during recovery; 750 mg L-carnitine significantly facilitated fat oxidation[11]
Practical Integration
Take L-carnitine with meals to enhance absorption. Green coffee extract works best taken before meals. Store all supplements in a cool, dry place away from direct sunlight. P-synephrine and caffeine-containing products should be consumed earlier in the day to avoid sleep disruption.
Common Mistakes to Avoid
- Expecting immediate results: Studies using less than 4 weeks of supplementation showed no measurable effect.[16] Commit to at least 8-12 weeks for evaluation.
- Inconsistent dosing: Clinical trials used daily dosing protocols. Sporadic use may not achieve the benefits demonstrated in research.
- Combining high-dose synephrine with caffeine: Laboratory evidence raises hepatotoxicity concerns with this combination.[23]
- Ignoring diet and exercise: Meta-analysis confirms diet and exercise are more effective than thermogenic supplements alone.[1]
⚖️ Thermogenic Supplements vs. Other Approaches
Understanding how thermogenic supplements compare to other weight management strategies helps you set realistic expectations and choose the most effective approach for your goals.
| Approach | Effectiveness | Evidence Level | Best For |
|---|---|---|---|
| Diet and Exercise | Superior to supplements alone | [A][1] | Primary weight loss strategy |
| Multi-ingredient Thermogenics | 121-166 kcal/day increase (acute) | [B][4] | Supplementing healthy lifestyle |
| CLA + Exercise | Decreased body fat vs. exercise alone | [A][25] | Active individuals, higher baseline BMI |
| CLA Alone | Small effects: -0.35 kg body mass | [A][24] | May not reach clinical importance |
| Natural Thermogenic Foods | ~34 kcal/day increase (capsaicinoids) | [A][2] | Dietary integration, lower risk |
Key Comparison Insights
Supplements vs. Diet/Exercise: A systematic review and meta-analysis of 21 studies directly comparing approaches found that weight-loss supplements showed less effectiveness than diet and exercise for both weight loss and cardiometabolic health outcomes.[Evidence: A][1] This underscores that supplements should complement—not replace—foundational lifestyle changes.
CLA Perspective: Meta-analysis of 70 randomized controlled trials involving 4,159 participants found conjugated linoleic acid produces small but statistically significant effects: body mass reduction of 0.35 kg, BMI reduction of 0.15 units, and waist circumference reduction of 0.62 cm. However, researchers note these weight-loss properties are small and may not reach clinical importance. High-quality studies tend to show more modest effects than lower-quality studies.[Evidence: A][24]
Synergistic Effects: CLA combined with exercise significantly decreased body fat and reduced insulin resistance compared to exercise alone, suggesting thermogenic supplements work best as part of an active lifestyle. Benefits were greatest in participants with higher baseline BMI and females.[Evidence: A][25]
What The Evidence Shows (And Doesn't Show)
What Research Suggests
The evidence base for thermogenic supplements includes 7 meta-analyses/systematic reviews and 18 randomized controlled trials, providing moderate overall confidence in the findings.
- Capsaicinoids from red pepper increase resting metabolic rate by approximately 34 kcal/day with increased fat oxidation and reduced respiratory quotient (13 studies analyzed).[Evidence: A][2]
- L-carnitine at optimal doses of 2000 mg/day significantly decreases body weight, BMI, and fat mass, with effects particularly notable in overweight/obese populations (37 RCTs, n=2,292).[Evidence: A][12]
- Green coffee bean extract at 500 mg chlorogenic acid/day produces measurable body weight reduction of approximately 1.30 kg, with one 12-week trial showing ~6% weight reduction in 97% of participants.[Evidence: A][14][15]
- Multi-ingredient thermogenic supplements increase resting energy expenditure by 121-166 kcal/day for 30-180 minutes post-ingestion.[Evidence: B][4]
- P-synephrine at 3 mg/kg increases maximal fat oxidation by 38% during exercise in males (0.40 vs 0.29 g/min).[Evidence: B][7]
What's NOT Yet Proven
- Long-term safety beyond 12 weeks: Most clinical trials lasted 4-12 weeks. Safety and efficacy data for chronic use (6+ months) remains extremely limited.
- Optimal dosage for all populations: Dose-response data exists for L-carnitine and p-synephrine, but optimal doses for other ingredients and specific populations remain unclear.
- Additive effects of ingredient combinations: Research shows caffeine and p-synephrine individually increase fat oxidation, but combining them does not produce additive effects.[Evidence: B][21]
- Effects in healthy-weight individuals: Most trials involved overweight/obese participants. Benefit magnitude in healthy-weight individuals seeking marginal improvements is not established.
- Superiority over diet and exercise: Meta-analysis confirms supplements showed less effectiveness than diet and exercise alone.[Evidence: A][1]
- Clinically meaningful weight loss: Some meta-analyses note effects "may not reach clinical importance."[Evidence: A][24] Novel formulations showed "clinically insignificant changes."[Evidence: B][27]
Where Caution Is Needed
- Synephrine + caffeine hepatotoxicity: In vitro studies demonstrate this combination at supplement-relevant concentrations causes liver cell damage and DNA toxicity.[Evidence: C][23]
- Sex differences in response: P-synephrine showed no significant effect on fat oxidation in women despite positive results in men, indicating sex-specific responses to certain compounds.[Evidence: B][9]
- Cardiovascular effects: Systolic blood pressure increases of 3-4 mmHg, while within normal ranges for healthy adults, may be concerning for those with hypertension.[Evidence: B][4]
- Minimum duration requirements: Supplementation for less than 4 weeks showed no measurable effect on body composition outcomes.[Evidence: A][16]
- Drug interactions: Clinical interaction data is limited; theoretical concerns exist for stimulant medications, MAOIs, and cardiovascular drugs.
Should YOU Try This?
Best suited for: Adults with BMI ≥25 kg/m² seeking modest supplementary support alongside established diet and exercise regimens. Those who have plateaued with lifestyle changes alone may see incremental benefit. Females may respond better to CLA combined with exercise than to p-synephrine.
Not recommended for: Pregnant or breastfeeding women; children and adolescents under 18; individuals with cardiovascular disease, uncontrolled hypertension, or liver conditions; those taking MAO inhibitors or stimulant medications; anyone allergic to ingredient components. Avoid high-dose synephrine + caffeine combinations.
Realistic timeline: Allow minimum 4 weeks before expecting any measurable changes; most positive trials lasted 8-12 weeks. Acute metabolic effects (energy expenditure increase) occur within 30-180 minutes of dosing. Weight/body composition changes require consistent long-term use.
When to consult a professional: Before starting any thermogenic supplement, especially if you have existing health conditions, take prescription medications, or have experienced adverse reactions to caffeine or stimulants. Healthcare provider should monitor blood pressure and liver function for long-term users.
Frequently Asked Questions
Can I take thermogenic supplements before bed?
Caffeine-containing thermogenic supplements should not be taken within 4-6 hours of bedtime. Studies show metabolic effects peak at 60-180 minutes post-ingestion and can persist for several hours. Caffeine has a half-life of approximately 5-6 hours, meaning half the stimulant remains active for that duration. Taking thermogenics too late disrupts sleep quality, which paradoxically impairs weight management through hormonal disruption. If you exercise in the evening, consider stimulant-free formulations containing ingredients like L-carnitine or chlorogenic acid, which don't affect sleep architecture.
Do thermogenic supplements work differently for women?
Research documents significant sex differences in thermogenic supplement response. A randomized controlled trial specifically examining p-synephrine in healthy active women found no significant effect on fat oxidation during exercise, despite earlier male-predominant studies showing positive results. While p-synephrine raised resting body temperature in women, no metabolic improvement occurred during exercise. This suggests women may need different approaches or ingredients. Conjugated linoleic acid studies show females actually experience greater benefits than males when combined with exercise. Consider individual response when selecting thermogenic compounds.
Are there effective caffeine-free thermogenic supplements?
Yes, several non-stimulant compounds demonstrate thermogenic effects. Capsaicinoids from red pepper increased resting metabolic rate by 33.99 kcal/day in meta-analysis. L-carnitine at 2000 mg/day significantly decreased body weight and fat mass without stimulant effects. Green coffee bean extract standardized for chlorogenic acid provides thermogenic benefits independent of caffeine content—studies used decaffeinated extracts showing improvements in blood pressure, glucose, and body composition. Forskolin from Coleus forskohlii also shows metabolic benefits without stimulation.
How long do thermogenic effects last after taking a supplement?
Acute thermogenic effects typically last 3-6 hours. Research shows resting metabolic rate increases significantly at 60, 120, and 180 minutes post-ingestion, with sustained effects for several hours in healthy participants. Multi-ingredient thermogenic supplements produced mean increases in resting energy expenditure of 121-166 kcal/day measured at 30-180 minutes after consumption. However, chronic adaptation occurs. Multi-ingredient thermogenic supplements maintained (rather than increased) fasted resting energy expenditure over 4 weeks of use, suggesting the body adapts to continuous exposure.
Do thermogenic supplements interact with medications?
Potential interactions exist but are not fully characterized in clinical literature. Caffeine-containing thermogenics may interact with stimulant medications, MAO inhibitors, and medications affecting heart rhythm. The combination of synephrine and caffeine raises particular concerns—laboratory studies showed this combination at supplement-relevant concentrations causes liver cell toxicity and DNA damage. While this is in vitro data, caution is warranted. Always inform your healthcare provider of all supplements and medications before starting thermogenics, especially if taking blood pressure medications, antidepressants, or blood thinners.
How much weight can I realistically lose with thermogenic supplements?
Evidence suggests modest rather than dramatic weight loss. Green coffee bean extract at 500 mg chlorogenic acid daily lowers body weight by approximately 1.30 kg according to meta-analysis. A 12-week trial with 500 mg green coffee extract twice daily achieved approximately 6% body weight reduction, with 97% of participants showing measurable weight loss. L-carnitine meta-analysis of 37 RCTs (n=2,292) confirms significant but modest reductions in body weight, BMI, and fat mass. Expect supplements to contribute to—not replace—comprehensive weight management.
What's the best dosage for thermogenic supplements?
Optimal dosages vary by ingredient and goal. For weight management, L-carnitine shows maximum effect at 2000 mg/day based on dose-response meta-analysis. Green coffee/chlorogenic acid doses of 500 mg/day demonstrate effectiveness for body weight reduction. For acute fat oxidation during exercise, p-synephrine at 2-3 mg/kg body weight produces the greatest effects—3 mg/kg achieved maximal fat oxidation of 0.55 ± 0.14 g/min compared to placebo at 0.35 ± 0.05 g/min. Start with lower doses to assess tolerance before increasing.
Do I need to cycle thermogenic supplements?
Evidence on cycling is limited, but chronic use data provides insights. Multi-ingredient thermogenic supplements maintained fasted resting energy expenditure over 4 weeks rather than continuing to increase it, suggesting metabolic adaptation. Body composition changes showed no significant differences compared to control over this period. Six-week interventions confirmed safety with maintained blood chemistry results, though fat loss benefits were not superior to placebo. Cycling (8-12 weeks on, 2-4 weeks off) may help maintain sensitivity, though specific cycling protocols lack robust clinical validation.
Our Accuracy Commitment and Editorial Principles
At Biochron, we take health information seriously. Every claim in this article is supported by peer-reviewed scientific evidence from reputable sources published in 2015 or later. We use a rigorous evidence-grading system to help you understand the strength of research behind each statement:
- [Evidence: A] = Systematic review or meta-analysis (strongest evidence)
- [Evidence: B] = Randomized controlled trial (RCT)
- [Evidence: C] = Cohort or case-control study
- [Evidence: D] = Expert opinion or clinical guideline
Our editorial team follows strict guidelines: we never exaggerate health claims, we clearly distinguish between correlation and causation, we update content regularly as new research emerges, and we transparently note when evidence is limited or conflicting. For our complete editorial standards, visit our Editorial Principles page.
This article is for informational purposes only and does not constitute medical advice. Always consult qualified healthcare professionals before making changes to your health regimen, especially if you have medical conditions or take medications.
References
- 1 . Comparing effectiveness of fat burners and thermogenic supplements to diet and exercise for weight loss and cardiometabolic health: Systematic review and meta-analysis. Clark JE, Welch S. Nutrition & Health, 2021; 27(4):445-459. DOI | PubMed [Evidence: A]
- 2 . The effect of Capsaicinoids or Capsinoids in red pepper on thermogenesis in healthy adults: A systematic review and meta-analysis. Irandoost P, et al. Phytotherapy Research, 2021; 35(3):1358-1377. DOI | PubMed [Evidence: A]
- 3 . Chronic Thermogenic Dietary Supplement Consumption: Effects on Body Composition, Anthropometrics, and Metabolism. Siedler MR, et al. Nutrients, 2023; 15(22):4806. DOI | PubMed [Evidence: B]
- 4 . The effects of a thermogenic supplement on metabolic and hemodynamic variables and subjective mood states. Prather JM, et al. Journal of the International Society of Sports Nutrition, 2023; 20(1):2185538. DOI | PubMed [Evidence: B]
- 5 . Influence of A Thermogenic Dietary Supplement on Safety Markers, Body Composition, Energy Expenditure, Muscular Performance and Hormone Concentrations. Tinsley GM, et al. Journal of Sports Science and Medicine, 2017; 16(4):459-467. PubMed [Evidence: B]
- 6 . Consuming a multi-ingredient thermogenic supplement for 28 days is apparently safe in healthy adults. Vogel RM, et al. Food and Nutrition Research, 2015; 59:27999. DOI | PubMed [Evidence: B]
- 7 . Acute p-synephrine ingestion increases fat oxidation rate during exercise. Gutiérrez-Hellín J, Del Coso J. British Journal of Clinical Pharmacology, 2016; 82(2):362-368. DOI | PubMed [Evidence: B]
- 8 . Dose-Response Effects of p-Synephrine on Fat Oxidation Rate During Exercise of Increasing Intensity. Gutiérrez-Hellín J, Del Coso J. Phytotherapy Research, 2018; 32(2):370-374. DOI | PubMed [Evidence: B]
- 9 . Effect of p-Synephrine on Fat Oxidation Rate during Exercise of Increasing Intensity in Healthy Active Women. Gutiérrez-Hellín J, et al. Nutrients, 2022; 14(20):4352. DOI | PubMed [Evidence: B]
- 10 . β3-Adrenergic receptors regulate human brown/beige adipocyte lipolysis and thermogenesis. Cero C, et al. JCI Insight, 2021; 6(11):e139160. DOI | PubMed [Evidence: B]
- 11 . Liver-Oriented Acute Metabolic Effects of A Low Dose of L-Carnitine under Fat-Mobilizing Conditions. Odo S, et al. Journal of Nutritional Science and Vitaminology, 2020; 66(2):136-149. DOI | PubMed [Evidence: B]
- 12 . Effects of l-carnitine supplementation on weight loss and body composition: A systematic review and meta-analysis of 37 randomized controlled clinical trials with dose-response analysis. Talenezhad N, et al. Clinical Nutrition ESPEN, 2020; 37:9-23. DOI | PubMed [Evidence: A]
- 13 . Coleus forskohlii Extract Supplementation in Conjunction with a Hypocaloric Diet Reduces the Risk Factors of Metabolic Syndrome. Loftus HL, et al. Nutrients, 2015; 7(11):9508-9522. DOI | PubMed [Evidence: B]
- 14 . Chlorogenic acid in green bean coffee on body weight: a systematic review and meta-analysis of randomized controlled trials. Kanchanasurakit S, et al. Systematic Reviews, 2023; 12(1):163. DOI | PubMed [Evidence: A]
- 15 . Clinical Evaluation of a Novel, Patented Green Coffee Bean Extract (GCB70®), Enriched in 70% Chlorogenic Acid, in Overweight Individuals. Verma N, et al. Journal of the American Nutritional Association, 2024; 43(4):315-325. DOI | PubMed [Evidence: B]
- 16 . The effect of green-coffee extract supplementation on obesity: A systematic review and dose-response meta-analysis of randomized controlled trials. Gorji Z, et al. Phytomedicine, 2019; 63:153018. DOI | PubMed [Evidence: A]
- 17 . Coffee Abundant in Chlorogenic Acids Reduces Abdominal Fat in Overweight Adults. Watanabe T, et al. Nutrients, 2019; 11(7):1617. DOI | PubMed [Evidence: B]
- 18 . Supplementation of green coffee bean extract in healthy overweight subjects increases lean mass/fat mass ratio. Sudeep HV, Shyam Prasad K. SAGE Open Medicine, 2021; 9:20503121211002590. DOI | PubMed [Evidence: B]
- 19 . Effects of green coffee extract supplementation on anthropometric indices, glycaemic control, blood pressure, lipid profile, insulin resistance and appetite in patients with the metabolic syndrome. Roshan H, et al. British Journal of Nutrition, 2018; 119(3):250-258. DOI | PubMed [Evidence: B]
- 20 . Effects of Caffeine on Brown Adipose Tissue Thermogenesis and Metabolic Homeostasis: A Review. Van Schaik L, et al. Frontiers in Neuroscience, 2021; 15:621356. DOI | PubMed [Evidence: D]
- 21 . Effects of p-Synephrine and Caffeine Ingestion on Substrate Oxidation during Exercise. Gutiérrez-Hellín J, Del Coso J. Medicine & Science in Sports & Exercise, 2018; 50(9):1899-1906. DOI | PubMed [Evidence: B]
- 22 . The Effects of Supplementation with p-Synephrine Alone and in Combination with Caffeine on Metabolic, Lipolytic, and Cardiovascular Responses during Resistance Exercise. Ratamess NA, et al. Journal of the American College of Nutrition, 2016; 35(8):657-669. DOI | PubMed [Evidence: B]
- 23 . Synephrine and caffeine combination promotes cytotoxicity, DNA damage and transcriptional modulation of apoptosis-related genes in human HepG2 cells. Leão TK, et al. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2021; 868-869:503375. DOI | PubMed [Evidence: C]
- 24 . The effects of conjugated linoleic acid supplementation on anthropometrics and body composition indices in adults: a systematic review and dose-response meta-analysis. Asbaghi O, et al. British Journal of Nutrition, 2024; 131(3):406-428. DOI | PubMed [Evidence: A]
- 25 . Effects of conjugated linoleic acid and exercise on body composition and obesity: a systematic review and meta-analysis. Liang CW, et al. Nutrition Reviews, 2023; 81(4):397-415. DOI | PubMed [Evidence: A]
- 26 . The effects of a single-dose thermogenic supplement on resting metabolic rate and hemodynamic variables in healthy females. Campbell BI, et al. Journal of the International Society of Sports Nutrition, 2016; 13:13. DOI PubMed
- 27 . An Examination of a Novel Weight Loss Supplement on Anthropometry and Indices of Cardiovascular Disease Risk. Sowinski RJ, et al. Journal of Dietary Supplements, <strong>2021; 18(5):478-506. DOI | PubMed
Medical Disclaimer
This content is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of such advice or treatment from a personal physician. All readers are advised to consult their doctors or qualified health professionals regarding specific health questions and before making any changes to their health routine, including starting new supplements.
Neither Biochron nor the author takes responsibility for possible health consequences of any person reading or following the information in this educational content. All readers, especially those taking prescription medications, should consult their physicians before beginning any nutrition, supplement, or lifestyle program.
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